IFIH1
| Gene Symbol | IFIH1 |
|---|---|
| Entrez Gene | 64135 |
| Alt Symbol | AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon induced with helicase C domain 1 |
| Other Description | CADM-140 autoantigen|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|RIG-I-like receptor 2|RNA helicase-DEAD box protein 116|clinically amyopathic dermatomyositis autoantigen 140 kDa|helicard|helicase with 2 CARD domains|interferon-induced helicase C domain-containing protein 1|melanoma differentiation associated protein-5|melanoma differentiation-associated protein 5|murabutide down-regulated protein |
| Swissprots | Q9H3G6 Q2NKL6 Q6DC96 Q86X56 Q96MX8 Q9BYX4 |
| Accessions | AAX93137 AAY24206 EAX11352 Q9BYX4 AF095844 AAG34368 AK056293 BAB71141 AK292941 BAF85630 AK314611 AY017378 AAG54076 BC007966 BC046208 AAH46208 BC078180 AAH78180 BC111750 AAI11751 BQ772836 BU902097 XM_011511628 XP_011509930 XM_011511629 XP_011509931 NM_022168 NP_071451 |
| Function | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:14645903}. Nucleus {ECO:0000305}. Note=May be found in the nucleus, during apoptosis. |
| Tissue Specificity | Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:12015121, ECO:0000269|PubMed:14645903}. |
| Top Pathways | RIG-I-like receptor signaling pathway, Measles, Influenza A, Herpes simplex infection |
MDA5 CRISPR/Cas9 KO Plasmid (h) - sc-401962 from Santa Cruz Biotechnology
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MDA5 HDR Plasmid (h) - sc-401962-HDR from Santa Cruz Biotechnology
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MDA5 Double Nickase Plasmid (h) - sc-401962-NIC from Santa Cruz Biotechnology
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MDA5 Double Nickase Plasmid (h2) - sc-401962-NIC-2 from Santa Cruz Biotechnology
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MDA5 CRISPR Activation Plasmid (h) - sc-401962-ACT from Santa Cruz Biotechnology
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MDA5 CRISPR Activation Plasmid (h2) - sc-401962-ACT-2 from Santa Cruz Biotechnology
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MDA5 Lentiviral Activation Particles (h) - sc-401962-LAC from Santa Cruz Biotechnology
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MDA5 Lentiviral Activation Particles (h2) - sc-401962-LAC-2 from Santa Cruz Biotechnology
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MDA5 siRNA (h) - sc-61010 from Santa Cruz Biotechnology
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MDA5 shRNA Plasmid (h) - sc-61010-SH from Santa Cruz Biotechnology
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MDA5 shRNA (h) Lentiviral Particles - sc-61010-V from Santa Cruz Biotechnology
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MDA5 RNAi - H00064135-R02 from Novus Biologicals
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MISSION® esiRNA - EHU008611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2487 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2487 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00278 from Sigma-Aldrich
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IFIH1 siRNA (Human) - CRJ1941 from Cohesion Biosciences
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IFIH1 - MBS8218924 from MyBioSource
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shRNA set against Human IFIH1 (NM_022168.3) - SHH316893 from Creative biogene
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IFIH1 shRNA Plasmid (Human) - CHJ1941 from Cohesion Biosciences
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IFIH1 miRNA 3'UTR clone - MiUTR3H-08852 from Creative biogene
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