IFIH1

Gene Symbol	IFIH1
Entrez Gene	64135
Alt Symbol	AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1
Species	Human
Gene Type	protein-coding
Description	interferon induced with helicase C domain 1
Other Description	CADM-140 autoantigen|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|RIG-I-like receptor 2|RNA helicase-DEAD box protein 116|clinically amyopathic dermatomyositis autoantigen 140 kDa|helicard|helicase with 2 CARD domains|interferon-induced helicase C domain-containing protein 1|melanoma differentiation associated protein-5|melanoma differentiation-associated protein 5|murabutide down-regulated protein
Swissprots	Q9H3G6 Q2NKL6 Q6DC96 Q86X56 Q96MX8 Q9BYX4
Accessions	AAX93137 AAY24206 EAX11352 Q9BYX4 AF095844 AAG34368 AK056293 BAB71141 AK292941 BAF85630 AK314611 AY017378 AAG54076 BC007966 BC046208 AAH46208 BC078180 AAH78180 BC111750 AAI11751 BQ772836 BU902097 XM_011511628 XP_011509930 XM_011511629 XP_011509931 NM_022168 NP_071451
Function	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:14645903}. Nucleus {ECO:0000305}. Note=May be found in the nucleus, during apoptosis.
Tissue Specificity	Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:12015121, ECO:0000269|PubMed:14645903}.
Top Pathways	RIG-I-like receptor signaling pathway, Measles, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MDA5 full length protein - ab131958 from Abcam Category Protein Source Wheat germ Species Human

Human MDA5 peptide - ab23050 from Abcam Category Peptide Species Human

Human MDA5 protein fragment - ab112423 from Abcam Category Protein Source Wheat germ Species Human

IFIH1 / MDA5 Antibody Blocking Peptide - LS-E25547 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IFIH1 / MDA5 Antibody Blocking Peptide - LS-E13072 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IFIH1 / MDA5 Antibody Blocking Peptide - LS-E26338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IFIH1 / MDA5 Antibody Blocking Peptide - LS-E30310 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IFIH1 / MDA5 Antibody Blocking Peptide - LS-E30311 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human MDA5 Protein - H00064135-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MDA5 Partial Recombinant Protein - H00064135-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MDA5 Blocking Peptide - NBP1-76761PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

MDA5 Peptide - NBP1-76760PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

MDA5 blocking peptide - GTX24544-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human IFIH1 protein - orb168545 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

IFIH1 Blocking Peptide - 33R-7591 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MDA5 Blocking Peptide - abx063945 from Abbexa Category Peptide Species Human, Rat

MDA5 Peptide - AC21-0376-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Helicard Control Peptide - AP30553CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Helicard Control Peptide - AP30554CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

MDA5 Peptide - 4039P from ProSci Category Peptide Species Human

MDA5 Peptide - 45-874P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

MDA5 Peptide - 4037P from ProSci Category Peptide Species Human

IFIH1 fusion protein - ag17448 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

IFIH1 fusion protein - Ag16467 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

IFIH1 Human - PRPS-1512 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Sf9 Insect Cells. Species Human

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