Gene Symbol | TCP1 |
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Entrez Gene | 6950 |
Alt Symbol | CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha |
Species | Human |
Gene Type | protein-coding |
Description | t-complex 1 |
Other Description | T-complex protein 1 subunit alpha|T-complex protein 1, alpha subunit|tailless complex polypeptide 1 |
Swissprots | Q5TCM3 Q15556 E1P5B2 P17987 |
Accessions | AAA61059 AAA61060 EAW47616 EAW47617 EAW47618 P17987 AA810047 AK308551 AK312604 BC000665 AAH00665 BM697304 BM827784 BT006969 AAP35615 DQ890600 ABM92217 DQ893771 ABM84697 X14986 X52882 CAA37064 NM_001008897 NP_001008897 NM_030752 NP_110379 |
Function | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}. |
Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
TCP-1 α CRISPR/Cas9 KO Plasmid (h) - sc-402699 from Santa Cruz Biotechnology
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TCP-1 α HDR Plasmid (h) - sc-402699-HDR from Santa Cruz Biotechnology
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TCP-1 α Double Nickase Plasmid (h) - sc-402699-NIC from Santa Cruz Biotechnology
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TCP-1 α Double Nickase Plasmid (h2) - sc-402699-NIC-2 from Santa Cruz Biotechnology
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TCP-1 α CRISPR Activation Plasmid (h) - sc-402699-ACT from Santa Cruz Biotechnology
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TCP-1 α CRISPR Activation Plasmid (h2) - sc-402699-ACT-2 from Santa Cruz Biotechnology
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TCP-1 α Lentiviral Activation Particles (h) - sc-402699-LAC from Santa Cruz Biotechnology
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TCP-1 α Lentiviral Activation Particles (h2) - sc-402699-LAC-2 from Santa Cruz Biotechnology
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TCP-1 α siRNA (h) - sc-36620 from Santa Cruz Biotechnology
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TCP-1 α shRNA Plasmid (h) - sc-36620-SH from Santa Cruz Biotechnology
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TCP-1 α shRNA (h) Lentiviral Particles - sc-36620-V from Santa Cruz Biotechnology
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TCP1 alpha RNAi - H00006950-R02 from Novus Biologicals
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TCP1 alpha RNAi - H00006950-R01 from Novus Biologicals
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MISSION® esiRNA - EHU015961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21162 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21162 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05626 from Sigma-Aldrich
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TCP1 siRNA (Human) - CRH4767 from Cohesion Biosciences
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TCP1 - MBS8220146 from MyBioSource
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shRNA set against Human TCP1 (NM_030752.2) - SHH425040 from Creative biogene
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TCP1 shRNA Plasmid (Human) - CHH4767 from Cohesion Biosciences
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TCP1 miRNA 3'UTR clone - MiUTR1H-10291 from Creative biogene
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TCP1 miRNA 3'UTR clone - MiUTR1H-10292 from Creative biogene
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