| Gene Symbol |
PGLYRP1
|
| Entrez Gene |
8993
|
| Alt Symbol |
PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidoglycan recognition protein 1
|
| Other Description |
TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
|
| Swissprots |
Q4VB36 O75594
|
| Accessions |
AAD38243 EAW57400 O75594 AF076483 AAC31822 AF242517 AAF99598 AY358936 AAQ89295 BC096154 AAH96154 BC096155 AAH96155 BC096156 AAH96156 BC096157 AAH96157 BC101845 AAI01846 BC101847 AAI01848 DN998360 NM_005091 NP_005082
|
| Function |
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:16354652}. Cytoplasmic granule {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:9707603}.
|