Gene Symbol | PGLYRP1 |
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Entrez Gene | 8993 |
Alt Symbol | PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L |
Species | Human |
Gene Type | protein-coding |
Description | peptidoglycan recognition protein 1 |
Other Description | TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein) |
Swissprots | Q4VB36 O75594 |
Accessions | AAD38243 EAW57400 O75594 AF076483 AAC31822 AF242517 AAF99598 AY358936 AAQ89295 BC096154 AAH96154 BC096155 AAH96155 BC096156 AAH96156 BC096157 AAH96157 BC101845 AAI01846 BC101847 AAI01848 DN998360 NM_005091 NP_005082 |
Function | Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:16354652}. Cytoplasmic granule {ECO:0000250}. |
Tissue Specificity | Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:9707603}. |
PGRP-S CRISPR/Cas9 KO Plasmid (h) - sc-411235 from Santa Cruz Biotechnology
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PGRP-S HDR Plasmid (h) - sc-411235-HDR from Santa Cruz Biotechnology
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PGRP-S Double Nickase Plasmid (h) - sc-411235-NIC from Santa Cruz Biotechnology
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PGRP-S Double Nickase Plasmid (h2) - sc-411235-NIC-2 from Santa Cruz Biotechnology
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PGRP-S CRISPR Activation Plasmid (h) - sc-411235-ACT from Santa Cruz Biotechnology
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PGRP-S CRISPR Activation Plasmid (h2) - sc-411235-ACT-2 from Santa Cruz Biotechnology
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PGRP-S Lentiviral Activation Particles (h) - sc-411235-LAC from Santa Cruz Biotechnology
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PGRP-S Lentiviral Activation Particles (h2) - sc-411235-LAC-2 from Santa Cruz Biotechnology
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PGRP-S siRNA (h) - sc-62790 from Santa Cruz Biotechnology
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PGRP-S shRNA Plasmid (h) - sc-62790-SH from Santa Cruz Biotechnology
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PGRP-S shRNA (h) Lentiviral Particles - sc-62790-V from Santa Cruz Biotechnology
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PGLYRP1/PGRP-S RNAi - H00008993-R02 from Novus Biologicals
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MISSION® esiRNA - EHU049471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16688 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16688 from Sigma-Aldrich
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PGLYRP1 siRNA (Human) - CRH5934 from Cohesion Biosciences
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shRNA set against Human PGLYRP1 (NM_005091.2) - SHH374280 from Creative biogene
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PGLYRP1 shRNA Plasmid (Human) - CHH5934 from Cohesion Biosciences
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PGLYRP1 miRNA 3'UTR clone - MiUTR3H-07248 from Creative biogene
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