MDFIC

Gene Symbol	MDFIC
Entrez Gene	29969
Alt Symbol	HIC
Species	Human
Gene Type	protein-coding
Description	MyoD family inhibitor domain containing
Other Description	I-mfa domain-containing protein|myoD family inhibitor domain-containing protein
Swissprots	Q9P1T7 Q9P1T6
Accessions	EAW83487 Q9P1T7 AA406528 AF054589 AAF36998 AI668639 AY196485 AAP33842 BC040713 BC156446 AAI56447 CB048531 NM_001166345 NP_001159817 NM_001166346 NP_001159818 NM_199072 NP_951038
Function	Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}.
Subcellular Location	Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.
Tissue Specificity	Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine. {ECO:0000269|PubMed:10671520}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MDFIC (L-12) - sc-163066 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MDFIC (G-13) - sc-163065 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MDFIC (D-15) - sc-163063 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MDFIC (Z-25) - sc-133775 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Rabbit Clonality Polyclonal

Anti-MDFIC antibody - ab198847 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC antibody - ab93224 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (N-Terminus, AP) - LS-C245015 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (N-Terminus, APC) - LS-C245016 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (N-Terminus, Biotin) - LS-C245017 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (aa188-237) - LS-C82651 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (N-Terminus, FITC) - LS-C245018 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (aa88-137) - LS-C82650 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (N-Terminus, PE) - LS-C245021 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (N-Terminus, Azide-free, HRP) - LS-C247697 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (N-Terminus) - LS-C327864 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC / HIC Antibody (aa73-99) - LS-C164104 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

MDFIC Antibody - NBP1-91378 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

MDFIC Antibody - NBP1-93698 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MDFIC Antibody - NBP1-91377 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

MDFIC Polyclonal Antibody - bs-6386R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC (AB1) antibody produced in rabbit - AV50877 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC antibody produced in rabbit - HPA030716 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MDFIC (AB2) antibody produced in rabbit - AV50878 from Sigma-Aldrich Prices $347.50, $347.50 Sizes 50 µg, 100 µl Host Rabbit Clonality Polyclonal

MDFIC antibody - N-terminal region (ARP50877_P050) - ARP50877_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MDFIC antibody - middle region (ARP50878_P050) - ARP50878_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Search more