| Gene Symbol | MDFIC |
|---|---|
| Entrez Gene | 29969 |
| Alt Symbol | HIC |
| Species | Human |
| Gene Type | protein-coding |
| Description | MyoD family inhibitor domain containing |
| Other Description | I-mfa domain-containing protein|myoD family inhibitor domain-containing protein |
| Swissprots | Q9P1T7 Q9P1T6 |
| Accessions | EAW83487 Q9P1T7 AA406528 AF054589 AAF36998 AI668639 AY196485 AAP33842 BC040713 BC156446 AAI56447 CB048531 NM_001166345 NP_001159817 NM_001166346 NP_001159818 NM_199072 NP_951038 |
| Function | Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Subcellular Location | Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm. |
| Tissue Specificity | Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine. {ECO:0000269|PubMed:10671520}. |