MDFIC

Gene Symbol	MDFIC
Entrez Gene	29969
Alt Symbol	HIC
Species	Human
Gene Type	protein-coding
Description	MyoD family inhibitor domain containing
Other Description	I-mfa domain-containing protein|myoD family inhibitor domain-containing protein
Swissprots	Q9P1T7 Q9P1T6
Accessions	EAW83487 Q9P1T7 AA406528 AF054589 AAF36998 AI668639 AY196485 AAP33842 BC040713 BC156446 AAI56447 CB048531 NM_001166345 NP_001159817 NM_001166346 NP_001159818 NM_199072 NP_951038
Function	Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}.
Subcellular Location	Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.
Tissue Specificity	Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine. {ECO:0000269|PubMed:10671520}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MDFIC peptide - ab86656 from Abcam Category Peptide

MDFIC / HIC Antibody Blocking Peptide - LS-E18373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDFIC / HIC Antibody Blocking Peptide - LS-E18374 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDFIC / HIC Antibody Blocking Peptide - LS-E9736 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDFIC-Antibody-N-term-Blocking-Peptide - BP8709a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MDFIC Blocking Peptide - 33R-8929 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MDFIC Blocking Peptide - 33R-7305 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Recombinant Human MyoD family inhibitor domain-containing protein(MDFIC) - CSB-YP889174HU CSB-EP889174HU CSB-BP889174HU CSB-MP889174HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MDFIC Protein - NBP1-93698PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MDFIC Peptide, Human - M34GP09334H from Creative Peptides Category Peptide Source Synthetic. Species Human

MyoD family inhibitor domain-containing protein (MDFIC), Recombinant Protein - MBS1366336 from MyBioSource Category Protein Prices $995.00, $995.00, $1,225.00, $1,225.00, $1,525.00, $1,525.00, $1,985.00, $1,985.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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