MDFIC

Gene Symbol MDFIC
Entrez Gene 29969
Alt Symbol HIC
Species Human
Gene Type protein-coding
Description MyoD family inhibitor domain containing
Other Description I-mfa domain-containing protein|myoD family inhibitor domain-containing protein
Swissprots Q9P1T7 Q9P1T6
Accessions EAW83487 Q9P1T7 AA406528 AF054589 AAF36998 AI668639 AY196485 AAP33842 BC040713 BC156446 AAI56447 CB048531 NM_001166345 NP_001159817 NM_001166346 NP_001159818 NM_199072 NP_951038
Function Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}.
Subcellular Location Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.
Tissue Specificity Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine. {ECO:0000269|PubMed:10671520}.

MDFIC CRISPR/Cas9 KO Plasmid (h) - sc-406712 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC HDR Plasmid (h) - sc-406712-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC Double Nickase Plasmid (h) - sc-406712-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC Double Nickase Plasmid (h2) - sc-406712-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC CRISPR Activation Plasmid (h) - sc-406712-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC CRISPR Activation Plasmid (h2) - sc-406712-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC Lentiviral Activation Particles (h) - sc-406712-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC Lentiviral Activation Particles (h2) - sc-406712-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDFIC siRNA (h) - sc-89686 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MDFIC shRNA Plasmid (h) - sc-89686-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MDFIC shRNA (h) Lentiviral Particles - sc-89686-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU056121 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13137 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13137 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MDFIC siRNA (Human) - CRH9307 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MDFIC (NM_199072.4) - SHH339579 from Creative biogene

Category siRNA
Species Reactivities Human

Human MDFIC siRNA - orb269809 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MDFIC shRNA Plasmid (Human) - CHH9307 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MDFIC miRNA 3'UTR clone - MiUTR4H-TG05426 from Creative biogene

Species Reactivities Human
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