| Gene Symbol |
KIAA0226
|
| Entrez Gene |
9711
|
| Alt Symbol |
RUBICON, SCAR15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KIAA0226
|
| Other Description |
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein|RUN domain protein as Beclin 1-interacting and cysteine-rich containing|baron|beclin-1 associated RUN domain containing protein|run domain Beclin-1 interacting and cystein-rich containing protein|run domain Beclin-1 interacting and cysteine-rich containing protein|rundataxin
|
| Swissprots |
Q96CK5 Q92622
|
| Accessions |
EAW92238 EAW92239 Q92622 AI796534 AK295625 BAG58502 BC014173 AAH14173 BC033615 AAH33615 BC160011 AAI60011 BU501990 BX647598 CAI46107 CN288121 D86979 BAA13215 DA007321 DB036516 DB075342 HY003277 XM_005269374 XP_005269431 XM_006713827 XP_006713890 XM_006713828 XP_006713891 XM_006713829 XP_006713892 XM_006713830 XP_006713893 XM_006713831 XP_006713894 NM_001145642 NP_001139114 NM_014687 NP_055502
|
| Function |
Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Late endosome {ECO:0000269|PubMed:19270696}. Lysosome {ECO:0000269|PubMed:19270696}. Early endosome {ECO:0000269|PubMed:19270696}. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endososome and not at all in the Golgi apparatus.
|