| Gene Symbol |
GCHFR
|
| Entrez Gene |
2644
|
| Alt Symbol |
GFRP, HsT16933, P35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GTP cyclohydrolase I feedback regulator
|
| Other Description |
GTP cyclohydrolase 1 feedback regulatory protein|GTP cyclohydrolase I feedback regulatory protein
|
| Swissprots |
B7ZLM8 B2R4L6 P30047 Q99749 Q2M1Q2
|
| Accessions |
AAB37337 EAW92442 EAW92443 P30047 AK223430 BAD97150 AK311872 BAG34813 BC112262 AAI12263 BC112264 AAI12265 BC143904 AAI43905 HQ258032 ADR82786 NM_005258 NP_005249
|
| Function |
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16778797}. Nucleus membrane {ECO:0000269|PubMed:16778797}. Cytoplasm, cytosol {ECO:0000269|PubMed:16778797}.
|
| Tissue Specificity |
In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). {ECO:0000269|PubMed:16778797}.
|