Gene Symbol | GCHFR |
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Entrez Gene | 2644 |
Alt Symbol | GFRP, HsT16933, P35 |
Species | Human |
Gene Type | protein-coding |
Description | GTP cyclohydrolase I feedback regulator |
Other Description | GTP cyclohydrolase 1 feedback regulatory protein|GTP cyclohydrolase I feedback regulatory protein |
Swissprots | B7ZLM8 B2R4L6 P30047 Q99749 Q2M1Q2 |
Accessions | AAB37337 EAW92442 EAW92443 P30047 AK223430 BAD97150 AK311872 BAG34813 BC112262 AAI12263 BC112264 AAI12265 BC143904 AAI43905 HQ258032 ADR82786 NM_005258 NP_005249 |
Function | Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16778797}. Nucleus membrane {ECO:0000269|PubMed:16778797}. Cytoplasm, cytosol {ECO:0000269|PubMed:16778797}. |
Tissue Specificity | In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). {ECO:0000269|PubMed:16778797}. |
GFRP CRISPR/Cas9 KO Plasmid (h) - sc-405353 from Santa Cruz Biotechnology
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GFRP HDR Plasmid (h) - sc-405353-HDR from Santa Cruz Biotechnology
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GFRP Double Nickase Plasmid (h) - sc-405353-NIC from Santa Cruz Biotechnology
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GFRP Double Nickase Plasmid (h2) - sc-405353-NIC-2 from Santa Cruz Biotechnology
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GFRP CRISPR Activation Plasmid (h) - sc-405353-ACT from Santa Cruz Biotechnology
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GFRP CRISPR Activation Plasmid (h2) - sc-405353-ACT-2 from Santa Cruz Biotechnology
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GFRP Lentiviral Activation Particles (h) - sc-405353-LAC from Santa Cruz Biotechnology
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GFRP Lentiviral Activation Particles (h2) - sc-405353-LAC-2 from Santa Cruz Biotechnology
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GFRP siRNA (h) - sc-105393 from Santa Cruz Biotechnology
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GFRP shRNA Plasmid (h) - sc-105393-SH from Santa Cruz Biotechnology
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GFRP shRNA (h) Lentiviral Particles - sc-105393-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9188 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9188 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12100 from Sigma-Aldrich
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GCHFR siRNA (Human) - CRH1758 from Cohesion Biosciences
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GCHFR - MBS8233978 from MyBioSource
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shRNA set against Human GCHFR (NM_005258.2) - SHH300010 from Creative biogene
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shRNA set against Human GCHFR(NM_005258.2) - SHH079797 from Creative biogene
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Human GCHFR siRNA - orb262260 from Biorbyt
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GCHFR shRNA Plasmid (Human) - CHH1758 from Cohesion Biosciences
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GCHFR miRNA 3'UTR clone - MiUTR1H-03984 from Creative biogene
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