| Gene Symbol |
ZBTB18
|
| Entrez Gene |
10472
|
| Alt Symbol |
C2H2-171, MRD22, RP58, TAZ-1, ZNF238
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger and BTB domain containing 18
|
| Other Description |
58 kDa repressor protein|transcriptional repressor RP58|translin-associated zinc finger protein 1|zinc finger and BTB domain-containing protein 18|zinc finger protein 238|zinc finger protein C2H2-171
|
| Swissprots |
Q9UD99 Q13397 Q5VU40 Q8N463 A8K5U3 Q99592
|
| Accessions |
CAA11262 EAW77097 EAW77098 EAW77099 Q99592 AJ001388 CAA04718 AK291408 BAF84097 AK293892 BAG57281 AL050055 BC036677 AAH36677 BC078175 CN409673 DC377579 U38896 AAA81368 W68199 X95072 CAA64468 XM_005273006 XP_005273063 NM_001278196 NP_001265125 NM_006352 NP_006343 NM_205768 NP_991331
|
| Function |
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. {ECO:0000269|PubMed:9756912}.
|
| Subcellular Location |
Nucleus. Note=Associates with condensed chromatin.
|
| Tissue Specificity |
Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.
|