ZBTB18
| Gene Symbol | ZBTB18 |
|---|---|
| Entrez Gene | 10472 |
| Alt Symbol | C2H2-171, MRD22, RP58, TAZ-1, ZNF238 |
| Species | Human |
| Gene Type | protein-coding |
| Description | zinc finger and BTB domain containing 18 |
| Other Description | 58 kDa repressor protein|transcriptional repressor RP58|translin-associated zinc finger protein 1|zinc finger and BTB domain-containing protein 18|zinc finger protein 238|zinc finger protein C2H2-171 |
| Swissprots | Q9UD99 Q13397 Q5VU40 Q8N463 A8K5U3 Q99592 |
| Accessions | CAA11262 EAW77097 EAW77098 EAW77099 Q99592 AJ001388 CAA04718 AK291408 BAF84097 AK293892 BAG57281 AL050055 BC036677 AAH36677 BC078175 CN409673 DC377579 U38896 AAA81368 W68199 X95072 CAA64468 XM_005273006 XP_005273063 NM_001278196 NP_001265125 NM_006352 NP_006343 NM_205768 NP_991331 |
| Function | Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. {ECO:0000269|PubMed:9756912}. |
| Subcellular Location | Nucleus. Note=Associates with condensed chromatin. |
| Tissue Specificity | Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues. |
RP58 CRISPR/Cas9 KO Plasmid (h) - sc-407058 from Santa Cruz Biotechnology
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RP58 HDR Plasmid (h) - sc-407058-HDR from Santa Cruz Biotechnology
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RP58 Double Nickase Plasmid (h) - sc-407058-NIC from Santa Cruz Biotechnology
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RP58 Double Nickase Plasmid (h2) - sc-407058-NIC-2 from Santa Cruz Biotechnology
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RP58 CRISPR Activation Plasmid (h) - sc-407058-ACT from Santa Cruz Biotechnology
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RP58 CRISPR Activation Plasmid (h2) - sc-407058-ACT-2 from Santa Cruz Biotechnology
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RP58 Lentiviral Activation Particles (h) - sc-407058-LAC from Santa Cruz Biotechnology
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RP58 Lentiviral Activation Particles (h2) - sc-407058-LAC-2 from Santa Cruz Biotechnology
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RP58 siRNA (h) - sc-88400 from Santa Cruz Biotechnology
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RP58 shRNA Plasmid (h) - sc-88400-SH from Santa Cruz Biotechnology
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RP58 shRNA (h) Lentiviral Particles - sc-88400-V from Santa Cruz Biotechnology
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ZNF238 RNAi - H00010472-R01 from Novus Biologicals
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ZNF238 RNAi - H00010472-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN23331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23331 from Sigma-Aldrich
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ZBTB18 siRNA (Human) - CRH7109 from Cohesion Biosciences
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ZBTB18 - MBS8216959 from MyBioSource
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shRNA set against Human ZNF238 (NM_006352.3) - SHH453388 from Creative biogene
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shRNA set against Human ZNF238(NM_205768.2) - SHL058598 from Creative biogene
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shRNA set against Human ZNF238(NM_006352.3) - SHL155964 from Creative biogene
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RP58 CRISPR/Cas9 KO Plasmid (h2) - sc-407058-KO-2 from Santa Cruz Biotechnology
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RP58 HDR Plasmid (h2) - sc-407058-HDR-2 from Santa Cruz Biotechnology
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Human ZBTB18 siRNA - orb267611 from Biorbyt
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ZBTB18 shRNA Plasmid (Human) - CHH7109 from Cohesion Biosciences
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ZNF238 miRNA 3'UTR clone - MiUTR1H-11530 from Creative biogene
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