| Gene Symbol |
Ripk3
|
| Entrez Gene |
56532
|
| Alt Symbol |
2610528K09Rik, AW107945, Rip3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
receptor-interacting serine-threonine kinase 3
|
| Other Description |
RIP-3|RIP-like protein kinase 3|mRIP3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
|
| Swissprots |
Q8K2Y2 Q3U3Z9 G3X8V8 Q9QZL0
|
| Accessions |
EDL36235 EDL36236 Q9QZL0 AA270784 AF178953 AAF03133 AK012177 AK154505 BAE32636 BC029210 AAH29210 BF658559 BY206463 BY209344 NM_001164107 NP_001157579 NM_001164108 NP_001157580 NM_019955 NP_064339
|
| Function |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19590578, ECO:0000269|PubMed:24012422, ECO:0000269|PubMed:24019532, ECO:0000269|PubMed:24095729}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000305}. Cell membrane. Mitochondrion {ECO:0000305}.
|
| Tissue Specificity |
Expressed in embryo and in adult spleen, liver, testis, heart, brain and lung.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, TNF signaling pathway
|