Ripk3

Gene Symbol	Ripk3
Entrez Gene	56532
Alt Symbol	2610528K09Rik, AW107945, Rip3
Species	Mouse
Gene Type	protein-coding
Description	receptor-interacting serine-threonine kinase 3
Other Description	RIP-3|RIP-like protein kinase 3|mRIP3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots	Q8K2Y2 Q3U3Z9 G3X8V8 Q9QZL0
Accessions	EDL36235 EDL36236 Q9QZL0 AA270784 AF178953 AAF03133 AK012177 AK154505 BAE32636 BC029210 AAH29210 BF658559 BY206463 BY209344 NM_001164107 NP_001157579 NM_001164108 NP_001157580 NM_019955 NP_064339
Function	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19590578, ECO:0000269|PubMed:24012422, ECO:0000269|PubMed:24019532, ECO:0000269|PubMed:24095729}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000305}. Cell membrane. Mitochondrion {ECO:0000305}.
Tissue Specificity	Expressed in embryo and in adult spleen, liver, testis, heart, brain and lung.
Top Pathways	Cytosolic DNA-sensing pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse RIPK3 ORF clone(NM_019955.2) - CDCL185984 from Creative Biomart Species Mouse Accession NM_019955.2

Mouse RIPK3 ORF clone(NM_019955.2) - CDCH397268 from Creative Biomart Species Mouse Accession NM_019955.2

Mouse RIPK3 ORF clone(NM_001164108.1) - CDCH397269 from Creative Biomart Species Mouse Accession NM_001164108.1

Mouse RIPK3 ORF clone(NM_001164107.1) - CDCH397270 from Creative Biomart Species Mouse Accession NM_001164107.1

Mouse Ripk3 ORF Clone(NM_019955.2) - CDCL173720 from Creative Biomart Species Mouse Accession NM_019955.2

Mouse Ripk3 ORF Clone(NM_001164107.1) - CDCL173721 from Creative Biomart Species Mouse Accession NM_001164107.1

Mouse Ripk3 ORF Clone(NM_001164107.1) - CDCR240311 from Creative Biomart Species Mouse Accession NM_001164107.1

Mouse Ripk3 ORF Clone(NM_001164108.1) - CDCR240312 from Creative Biomart Species Mouse Accession NM_001164108.1

Mouse Ripk3 ORF Clone(NM_001164108.1) - CDCR240313 from Creative Biomart Species Mouse Accession NM_001164108.1

Mouse Ripk3 ORF Clone(NM_019955.2) - CDCR254562 from Creative Biomart Species Mouse Accession NM_019955.2

Mouse Ripk3 ORF Clone(NM_019955.2) - CDCR254563 from Creative Biomart Species Mouse Accession NM_019955.2

Mouse RIPK3 Gene ORF cDNA clone in cloning vector - MG51069-G from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, C-Flag tag - MG51069-CF from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, C-His tag - MG51069-CH from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - MG51069-ACR from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - MG51069-ANR from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, C-HA tag - MG51069-CY from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, C-Myc tag - MG51069-CM from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, N-Myc tag - MG51069-NM from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, N-His tag - MG51069-NH from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, N-HA tag - MG51069-NY from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid - MG51069-G-N from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid - MG51069-UT from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - MG51069-ACG from Sino Biological Species Mouse

Mouse RIPK3 Gene ORF cDNA clone expression plasmid, N-Flag tag - MG51069-NF from Sino Biological Species Mouse

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