Ripk3

Gene Symbol	Ripk3
Entrez Gene	56532
Alt Symbol	2610528K09Rik, AW107945, Rip3
Species	Mouse
Gene Type	protein-coding
Description	receptor-interacting serine-threonine kinase 3
Other Description	RIP-3|RIP-like protein kinase 3|mRIP3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots	Q8K2Y2 Q3U3Z9 G3X8V8 Q9QZL0
Accessions	EDL36235 EDL36236 Q9QZL0 AA270784 AF178953 AAF03133 AK012177 AK154505 BAE32636 BC029210 AAH29210 BF658559 BY206463 BY209344 NM_001164107 NP_001157579 NM_001164108 NP_001157580 NM_019955 NP_064339
Function	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19590578, ECO:0000269|PubMed:24012422, ECO:0000269|PubMed:24019532, ECO:0000269|PubMed:24095729}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000305}. Cell membrane. Mitochondrion {ECO:0000305}.
Tissue Specificity	Expressed in embryo and in adult spleen, liver, testis, heart, brain and lung.
Top Pathways	Cytosolic DNA-sensing pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

RIPK3/RIP3 Blocking Peptide - NBP1-77299PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg

RIP3 peptide - GTX28464 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Mouse

Mouse RIPK3 Protein - abx068835 from Abbexa Category Protein Source E.coli Species Mouse

RIPK3 / RIP3 Control Peptide - AP30729CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RIP3 Peptide - 2283P from ProSci Category Peptide Species Mouse

Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 3(Ripk3) - CSB-YP886403MO CSB-EP886403MO CSB-BP886403MO CSB-MP886403MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

RIP3 Blocking Peptide - 3293BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

RIP3, Peptide - MBS843572 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Synthetic Mouse RIPK3 (aa 473-486) Blocking Peptide - PX096BP from Cell Science Category Peptide Prices $170.00 Sizes 50 μg Species Mouse

Ripk3 Recombinant Protein (OPCA03079) - OPCA03079 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Species Mouse

Mouse Ripk3 protein - orb358306 from Biorbyt Category Protein Prices $221.00, $366.00, $646.00, $1,071.00, $1,692.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Mouse

RIPK3 Recombinant Protein (OPCD06698) - OPCD06698 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Recombinant Mus musculus Receptor-interacting serine/threonine-protein kinase 3 - AP73139 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

Receptor-interacting serine/threonine-protein kinase 3, Recombinant Protein - MBS1413422 from MyBioSource Category Protein Prices $110.00, $190.00, $285.00, $460.00, $750.00, $905.00, $1,115.00, $1,180.00, $1,215.00, $1,340.00, $1,365.00, $1,415.00, $1,905.00, $2,030.00, $2,060.00, $2,670.00 Sizes 10 µg (Yeast), 50 µg (Yeast), 100 µg (Yeast), 200 µg (Yeast), 500 µg (Yeast), 50 µg (E-Coli), 50 µg (Baculovirus), 1 mg (Yeast), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Receptor-interacting serine/threonine-protein kinase 3, Recombinant Protein - MBS9422835 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Mouse

Recombinant Mouse RIPK3 Protein (1-486 aa), His-tagged - RIPK3-1723M from Creative Biomart Category Protein Source Yeast Species Mouse

Search more