Gene Symbol | REG4 |
---|---|
Entrez Gene | 83998 |
Alt Symbol | GISP, REG-IV, RELP |
Species | Human |
Gene Type | protein-coding |
Description | regenerating islet-derived family, member 4 |
Other Description | REG-4|REG-like protein|gastrointestinal secretory protein|reg IV|regenerating gene type IV|regenerating islet-derived protein 4|regenerating islet-derived protein IV |
Swissprots | Q8NER7 Q8NER6 Q9BYZ8 |
Accessions | CAK22302 EAW56711 EAW56712 EAW56713 EAW56714 Q9BYZ8 AF254415 AAK48435 AF345934 AAK59869 AK057107 AY007243 AAG02562 AY126670 AAM95598 AY126671 AAM95599 AY126672 AAM95600 BC017089 AAH17089 BF242936 DQ891767 ABM82693 DQ894951 ABM85877 NM_001159352 NP_001152824 NM_001159353 NP_001152825 NM_032044 NP_114433 |
Function | Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. {ECO:0000269|PubMed:12819006, ECO:0000269|PubMed:20692269}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:12819006}. |
Tissue Specificity | Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells. {ECO:0000269|PubMed:11311942, ECO:0000269|PubMed:12455032, ECO:0000269|PubMed:12819006}. |