REG4

Gene Symbol	REG4
Entrez Gene	83998
Alt Symbol	GISP, REG-IV, RELP
Species	Human
Gene Type	protein-coding
Description	regenerating islet-derived family, member 4
Other Description	REG-4\|REG-like protein\|gastrointestinal secretory protein\|reg IV\|regenerating gene type IV\|regenerating islet-derived protein 4\|regenerating islet-derived protein IV
Swissprots	Q8NER7 Q8NER6 Q9BYZ8
Accessions	CAK22302 EAW56711 EAW56712 EAW56713 EAW56714 Q9BYZ8 AF254415 AAK48435 AF345934 AAK59869 AK057107 AY007243 AAG02562 AY126670 AAM95598 AY126671 AAM95599 AY126672 AAM95600 BC017089 AAH17089 BF242936 DQ891767 ABM82693 DQ894951 ABM85877 NM_001159352 NP_001152824 NM_001159353 NP_001152825 NM_032044 NP_114433
Function	Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. {ECO:0000269\|PubMed:12819006, ECO:0000269\|PubMed:20692269}.
Subcellular Location	Secreted {ECO:0000269\|PubMed:12819006}.
Tissue Specificity	Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells. {ECO:0000269\|PubMed:11311942, ECO:0000269\|PubMed:12455032, ECO:0000269\|PubMed:12819006}.

Reg IV (H-40) - sc-67187 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Reg IV (H-40): sc-67187. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intes-tine tissue showing cytoplasmic staining of glandular cells.

Reg IV (K-16) - sc-48077 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Reg IV (Lc07) - sc-80320 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

Anti-REG4 antibody - ab200723 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-REG4 antibody (ab200723)Lane 1 : HEK293T whole cell lysateLane 2 : RAW 264.7 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-REG4 antibody [MM0524-9B21] - ab89917 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	MM0524-9B21

IHC image of REG4 staining in Human colon Adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab89917, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-REG4 / REG-IV Antibody (aa29-140, FITC) - LS-C303802 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-REG4 / REG-IV Antibody (aa29-140, Biotin) - LS-C300852 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-REG4 / REG-IV Antibody (aa29-140) - LS-C296199 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant REG4 / REG-IV.

Reg4 Antibody [Unconjugated] - AF1379 from Novus Biologicals

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Goat
Clonality	Polyclonal

Reg4 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Goat Anti-Human Reg4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1379) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reg4 Antibody - 46130002 from Novus Biologicals

Prices	$299.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Reg4 Antibody - NBP2-38552 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: Reg4 Antibody [NBP2-38552] - Staining of human small intestine shows strong cytoplasmic positivity in goblet cells.

Reg4 Antibody (MM0524-9B21) - NBP2-11864 from Novus Biologicals

Prices	$349.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	MM0524-9B21

Reg4 Antibody [Biotin] - BAF1379 from Novus Biologicals

Prices	$390.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Human Reg4 Antibody - AF1379 from R&D Systems

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Goat

Reg4 in Human Colon Cancer Tissue. Reg4 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Goat Anti-Human Reg4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1379) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013 ). Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008 ) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections .

Human Reg4 Affinity Purified Polyclonal Ab, Goat IgG - AF1379-SP from R&D Systems

Host	Goat
Clonality	Polyclonal

Human Reg4 Antibody - MAB1379 from R&D Systems

Prices	$99.00, $339.00
Sizes	25 µg, 500 µg
Host	Mouse
Clone	200214

Human Reg4 MAb (Clone 200214), Mouse IgG2B - MAB1379-SP from R&D Systems

Host	Mouse
Clonality	Monoclonal
Clone	200214

Human Reg4 Biotinylated Antibody - BAF1379 from R&D Systems

Prices	$390.00
Sizes	50 µg
Host	Goat

REG4 antibody - orb6868 from Biorbyt

Prices	$255.00, $340.00
Sizes	100 μg, 200 μg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed and paraffin embedded human placenta (Dilution at:1:200) using REG4 antibody

REG4 antibody - 70R-19853 from Fitzgerald

Prices	$375.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

REG4 Antibody - abx121207 from Abbexa

Host	Rabbit
Clonality	Polyclonal

REG4 Antibody - abx103863 from Abbexa

Host	Rabbit
Clonality	Polyclonal

REG4 antibody - 12268-1-AP from Acris Antibodies

Prices	$270.00
Sizes	150 µl
Host	Rabbit
Clonality	Polyclonal

SGC-7901 cell were subjected to SDS PAGE followed by western blot with 12268-1-AP(REG4 Antibody) at dilution of 1:1000

Anti-Regenerating Islet Derived Protein 4 (REG4) - 20-4146 from ARP American Research Products

Prices	$319.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Reg IV antibody - STJ95405 from St John's Laboratory Ltd

Host	Rabbit
Clonality	Polyclonal

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