| Gene Symbol | ACVR2B |
|---|---|
| Entrez Gene | 93 |
| Alt Symbol | ACTRIIB, ActR-IIB, HTX4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | activin A receptor, type IIB |
| Other Description | activin receptor type-2B |
| Swissprots | Q4VAV0 Q13705 |
| Accessions | AAC64515 BAA24180 EAW64536 Q13705 AB209449 BAD92686 AF075005 AAC28458 BC096243 AAH96243 BC096244 AAH96244 BC096245 AAH96245 BC099642 AAH99642 BP352716 X77533 CAA54671 XM_005265583 XP_005265640 NM_001106 NP_001097 |
| Function | Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated rece |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Top Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |