ACVR2B

Gene Symbol	ACVR2B
Entrez Gene	93
Alt Symbol	ACTRIIB, ActR-IIB, HTX4
Species	Human
Gene Type	protein-coding
Description	activin A receptor, type IIB
Other Description	activin receptor type-2B
Swissprots	Q4VAV0 Q13705
Accessions	AAC64515 BAA24180 EAW64536 Q13705 AB209449 BAD92686 AF075005 AAC28458 BC096243 AAH96243 BC096244 AAH96244 BC096245 AAH96245 BC099642 AAH99642 BP352716 X77533 CAA54671 XM_005265583 XP_005265640 NM_001106 NP_001097
Function	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated rece
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ACVR2B gene - orb90823 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-ACVR2B-cDNA-Clone - DC09066 from Abgent, a WuXi AppTec company Prices $691.20 Sizes 10 µg Species Human Accession BC096243

ACVR2B - MBS1266796 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC096243

Human ACVR2B ORF clone(NM_001106.3) - CDCL182573 from Creative Biomart Species Human Accession NM_001106.3

Human ACVR2B ORF Clone(NM_001106.3) - CDCL153084 from Creative Biomart Species Human Accession NM_001106.3

Human ACVR2B/Activin RIIB Gene ORF cDNA clone in cloning vector - HG10229-M from Sino Biological Species Human

Human ACVR2B Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-tagged - HG10229-M-F from Sino Biological Species Human Accession NM_001106.3

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid - HG10229-UT from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, C-HA tag - HG10229-CY from Sino Biological Species Human

Human ACVR2B Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10229-M-N from Sino Biological Species Human Accession NM_001106.3

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10229-NF from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10229-CF from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, C-His tag - HG10229-CH from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10229-NM from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, N-HA tag - HG10229-NY from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10229-CM from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10229-ACG from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10229-ACR from Sino Biological Species Human

Human ACVR2B/Activin RIIB Gene ORF cDNA clone expression plasmid, N-His tag - HG10229-NH from Sino Biological Species Human

Human Activin RIIB (NP_001097) VersaClone cDNA - RDC1462 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

Human ACVR2B ORF clone(NM_001106.3) - CDCL182573 from Creative biogene Species Human

Human ACVR2B ORF Clone (BC096243) - CDCS407606 from Creative biogene Species Human Accession Q13705

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