ACVR2B

Gene Symbol	ACVR2B
Entrez Gene	93
Alt Symbol	ACTRIIB, ActR-IIB, HTX4
Species	Human
Gene Type	protein-coding
Description	activin A receptor, type IIB
Other Description	activin receptor type-2B
Swissprots	Q4VAV0 Q13705
Accessions	AAC64515 BAA24180 EAW64536 Q13705 AB209449 BAD92686 AF075005 AAC28458 BC096243 AAH96243 BC096244 AAH96244 BC096245 AAH96245 BC099642 AAH99642 BP352716 X77533 CAA54671 XM_005265583 XP_005265640 NM_001106 NP_001097
Function	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated rece
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ACVR2B-Over-expression-Lysate - LY12111a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ACVR2B overexpression lysate - LY400448 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ACVR2B 293 Cell Lysate - 400459 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Activin RIIB Overexpression Lysate (Native) - NBL1-07297 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ACVR2B Over-expression Lysate Product - GWB-E7F579 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Cynomolgus ACVR2B / ACTRIIB HEK293 Cell Lysate (WB positive control) - 90056-CCCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Cynomolgus ACVR2B / ACTRIIB HEK293 Cell Lysate (WB positive control) - 90056-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Cynomolgus ACVR2B / ACTRIIB HEK293 Cell Lysate (WB positive control) - 90056-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human ACVR2B / ActivinR-IIB HEK293 Cell Lysate (WB positive control) - 10229-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human ACVR2B / ActivinR-IIB HEK293 Cell Lysate (WB positive control) - 10229-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human ACVR2B Human Cells Transfected Lysate (positive control) (denatured) - orb172762 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Activin RIIB Overexpression Lysate (Denatured) - H00000093-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human ACVR2B Human Cells Transfected Lysate (positive control) (denatured) - orb173123 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human ACVR2B Knockdown Stable Cell Line - CSC-DC000218 from Creative biogene Category Cell Line Species Human

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