ACVR2B

Gene Symbol	ACVR2B
Entrez Gene	93
Alt Symbol	ACTRIIB, ActR-IIB, HTX4
Species	Human
Gene Type	protein-coding
Description	activin A receptor, type IIB
Other Description	activin receptor type-2B
Swissprots	Q4VAV0 Q13705
Accessions	AAC64515 BAA24180 EAW64536 Q13705 AB209449 BAD92686 AF075005 AAC28458 BC096243 AAH96243 BC096244 AAH96244 BC096245 AAH96245 BC099642 AAH99642 BP352716 X77533 CAA54671 XM_005265583 XP_005265640 NM_001106 NP_001097
Function	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated rece
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Activin Receptor Type IIB protein fragment - ab155714 from Abcam Category Protein Prices $352.00 Sizes 200 µg Source HEK 293 cells Species Human

Human Activin Receptor Type IIB full length protein - ab114487 from Abcam Category Protein Source Wheat germ Species Human

Human Activin Receptor Type IIB protein fragment - ab114488 from Abcam Category Protein Source Wheat germ Species Human

Human Activin Receptor Type IIB protein fragment - ab125577 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Activin Receptor Type IIB protein fragment - ab151386 from Abcam Category Protein Source HEK 293 cells Species Human

ACTRIIB / ACVR2B Antibody Blocking Peptide - LS-E2804 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACTRIIB / ACVR2B Antibody Blocking Peptide - LS-E8694 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACTRIIB / ACVR2B Antibody Blocking Peptide - LS-E16527 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Activin RIIB Partial Recombinant Protein - H00000093-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Activin RIIB Protein - H00000093-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Activin RIIB Blocking Peptide - NBP1-59708PEP from Novus Biologicals Category Peptide Prices $169.00 Sizes 100 µg Species Human

Activin RIIB Peptide - P2246 from Novus Biologicals Category Peptide Species Human

ACVR2B-Antibody-C-term-V474-Blocking-Peptide - BP7105b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ACVR2B-Antibody-N-term-Blocking-Peptide - BP7105a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Activin RIIB Fc Chimera (NS0), CF - 339-RB-100/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Activin RIIB Fc Chimera (NS0-expressed) - 339-RB-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Activin RIIB Fc Chimera (Sf 21), CF - 339-RBB-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Cynomolgus ACVR2B protein - orb138125 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells

Mouse ACVR2B His tag protein - orb83510 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Mouse Species Human

Human ACVR2B His tag protein - orb83262 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Cynomolgus ACVR2B protein (His Tag) - orb138124 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells

Human ACVR2B Fc tag protein - orb82846 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Human ACVR2B protein - orb180163 from Biorbyt Category Protein Prices $213.00, $408.00, $1,411.00, $1,981.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source Human Cells Species Human

ACVR2B Blocking Peptide - 33R-3706 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ACVR2B Blocking Peptide - 33R-4822 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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