| Gene Symbol |
AES
|
| Entrez Gene |
166
|
| Alt Symbol |
AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
amino-terminal enhancer of split
|
| Other Description |
gp130-associated protein GAM|groucho-related protein 5
|
| Swissprots |
Q96TG9 B2RBL0 Q9UDY9 Q14CJ1 Q08117 Q12808
|
| Accessions |
AAC72103 AAD00654 EAW69341 EAW69342 EAW69343 EAW69344 EAW69345 EAW69346 EAW69347 Q08117 AF072902 AAC35517 AF269289 AAG23172 AK094591 BAG52894 AK095154 AK314713 BAG37257 BC113735 AAI13736 BC113737 AAI13738 BG696926 BG913049 BM550097 BM908356 HQ258149 ADR82903 N23852 U04241 AAA16223 X73357 X73358 CAA51768 XM_006722664 XP_006722727 XM_011527745 XP_011526047 NM_001130 NP_001121 NM_198969 NP_945320 NM_198970 NP_945321
|
| Function |
Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
|
![Western Blot: GRG (Groucho homolog) Overexpression Lysate (Adult Normal) [NBP2-10957] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GRG (Groucho homolog).](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2370_GRG%2520(Groucho%2520homolog)%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10957-img0001.jpg)