Gene Symbol | AES |
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Entrez Gene | 166 |
Alt Symbol | AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5 |
Species | Human |
Gene Type | protein-coding |
Description | amino-terminal enhancer of split |
Other Description | gp130-associated protein GAM|groucho-related protein 5 |
Swissprots | Q96TG9 B2RBL0 Q9UDY9 Q14CJ1 Q08117 Q12808 |
Accessions | AAC72103 AAD00654 EAW69341 EAW69342 EAW69343 EAW69344 EAW69345 EAW69346 EAW69347 Q08117 AF072902 AAC35517 AF269289 AAG23172 AK094591 BAG52894 AK095154 AK314713 BAG37257 BC113735 AAI13736 BC113737 AAI13738 BG696926 BG913049 BM550097 BM908356 HQ258149 ADR82903 N23852 U04241 AAA16223 X73357 X73358 CAA51768 XM_006722664 XP_006722727 XM_011527745 XP_011526047 NM_001130 NP_001121 NM_198969 NP_945320 NM_198970 NP_945321 |
Function | Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver. |
Human Amino-terminal enhancer of split full length protein - ab104756 from Abcam
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Human Amino-terminal enhancer of split peptide - ab16684 from Abcam
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AES / Groucho Antibody Blocking Peptide - LS-E2984 from LifeSpan Bioscience
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AES / Groucho Antibody Blocking Peptide - LS-E27698 from LifeSpan Bioscience
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AES / Groucho Antibody Blocking Peptide - LS-E30175 from LifeSpan Bioscience
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AES / Groucho Antibody Blocking Peptide - LS-E30176 from LifeSpan Bioscience
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AES / Groucho Antibody Blocking Peptide - LS-E13093 from LifeSpan Bioscience
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AES / Groucho Antibody Blocking Peptide - LS-E11304 from LifeSpan Bioscience
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AES / Groucho Antibody Blocking Peptide - LS-E11303 from LifeSpan Bioscience
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GRG (Groucho homolog) Partial Recombinant Protein - H00000166-Q01 from Novus Biologicals
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GRG (Groucho homolog) Recombinant Protein - H00000166-P01 from Novus Biologicals
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GRG (Groucho homolog) Blocking Peptide - NBP1-76646PEP from Novus Biologicals
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GRG (Groucho homolog) Blocking Peptide - NBP1-76645PEP from Novus Biologicals
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Recombinant Human GRG (Groucho homolog) Protein - NBP1-51027 from Novus Biologicals
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AES-Antibody-C-term-Blocking-peptide - BP14115b from Abgent, a WuXi AppTec company
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AES Protein (OPPA00098) - OPPA00098 from Aviva Systems Biology
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Human AES protein - orb167863 from Biorbyt
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AES Blocking Peptide - 33R-3767 from Fitzgerald
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AES Blocking Peptide - 33R-3414 from Fitzgerald
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AES protein (His tag) - 80R-1712 from Fitzgerald
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Amino-Terminal Enhancer Of Split Peptide - AC21-2514-P from Abcore
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AES / ESP1 (1-197, His-tag) - AR09894PU-L from Acris Antibodies
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AES / ESP1 (1-197, His-tag) - AR09894PU-N from Acris Antibodies
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AES / ESP1 - H00000166-P01-10 from Acris Antibodies
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AES / ESP1 - H00000166-P01-25 from Acris Antibodies
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