AES

Gene Symbol	AES
Entrez Gene	166
Alt Symbol	AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5
Species	Human
Gene Type	protein-coding
Description	amino-terminal enhancer of split
Other Description	gp130-associated protein GAM|groucho-related protein 5
Swissprots	Q96TG9 B2RBL0 Q9UDY9 Q14CJ1 Q08117 Q12808
Accessions	AAC72103 AAD00654 EAW69341 EAW69342 EAW69343 EAW69344 EAW69345 EAW69346 EAW69347 Q08117 AF072902 AAC35517 AF269289 AAG23172 AK094591 BAG52894 AK095154 AK314713 BAG37257 BC113735 AAI13736 BC113737 AAI13738 BG696926 BG913049 BM550097 BM908356 HQ258149 ADR82903 N23852 U04241 AAA16223 X73357 X73358 CAA51768 XM_006722664 XP_006722727 XM_011527745 XP_011526047 NM_001130 NP_001121 NM_198969 NP_945320 NM_198970 NP_945321
Function	Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}.
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TLE5 CRISPR/Cas9 KO Plasmid (h) - sc-407025 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 HDR Plasmid (h) - sc-407025-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 Double Nickase Plasmid (h) - sc-407025-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 Double Nickase Plasmid (h2) - sc-407025-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 CRISPR Activation Plasmid (h) - sc-407025-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 CRISPR Activation Plasmid (h2) - sc-407025-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 Lentiviral Activation Particles (h) - sc-407025-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 Lentiviral Activation Particles (h2) - sc-407025-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TLE5 siRNA (h) - sc-63133 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TLE5 shRNA Plasmid (h) - sc-63133-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TLE5 shRNA (h) Lentiviral Particles - sc-63133-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRG (Groucho homolog) RNAi - H00000166-R03 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU079841 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2911 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2911 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

AES siRNA (Human) - CRH0120 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GRG (Groucho homolog) RNAi - H00000166-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

GRG (Groucho homolog) RNAi - H00000166-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

AES - MBS8223619 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human AES(NM_198970.1) - SHG044609 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human AES(NM_001130.5) - SHG044737 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human AES(NM_198969.1) - SHG044755 from Creative biogene Category siRNA Species Reactivities Human

AES shRNA Plasmid (Human) - CHH0120 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

AES miRNA 3'UTR clone - MiUTR1H-00225 from Creative biogene Species Reactivities Human

AES miRNA 3'UTR clone - MiUTR1H-00226 from Creative biogene Species Reactivities Human

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