SNAP25
| Gene Symbol | SNAP25 |
|---|---|
| Entrez Gene | 6616 |
| Alt Symbol | RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | synaptosomal-associated protein, 25kDa |
| Other Description | SUP|resistance to inhibitors of cholinesterase 4 homolog|super protein|synaptosomal-associated protein 25|synaptosomal-associated protein, 25kD |
| Swissprots | D3DW17 B2RAU4 Q53EM2 Q5U0B5 P60880 D3DW16 |
| Accessions | EAX10346 EAX10347 EAX10348 EAX10349 EAX10350 EAX10351 EAX10352 EAX10353 P60880 AK026732 AK090857 AK094560 AK098347 AK098767 AK223617 BAD97337 AK289647 BAF82336 AK314359 BAG36991 AM393230 CAL38108 AM393653 CAL38529 BC010647 AAH10647 BI552777 BI602062 BI604120 BT019684 AAV38490 BX647443 D21267 BAA22370 HQ447952 ADQ32436 L19760 AAC37545 L19761 AAC37546 XM_005260808 XP_005260865 XM_005260810 XP_005260867 NM_003081 NP_003072 NM_130811 NP_570824 |
| Function | t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. |
| Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity). {ECO:0000250}. |
| Tissue Specificity | Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum. |
| Top Pathways | Synaptic vesicle cycle |
SNAP 25 CRISPR/Cas9 KO Plasmid (h) - sc-401138 from Santa Cruz Biotechnology
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SNAP 25 HDR Plasmid (h) - sc-401138-HDR from Santa Cruz Biotechnology
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SNAP 25 Double Nickase Plasmid (h) - sc-401138-NIC from Santa Cruz Biotechnology
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SNAP 25 Double Nickase Plasmid (h2) - sc-401138-NIC-2 from Santa Cruz Biotechnology
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SNAP 25 CRISPR Activation Plasmid (h) - sc-401138-ACT from Santa Cruz Biotechnology
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SNAP 25 CRISPR Activation Plasmid (h2) - sc-401138-ACT-2 from Santa Cruz Biotechnology
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SNAP 25 Lentiviral Activation Particles (h) - sc-401138-LAC from Santa Cruz Biotechnology
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SNAP 25 Lentiviral Activation Particles (h2) - sc-401138-LAC-2 from Santa Cruz Biotechnology
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SNAP 25 siRNA (h) - sc-36517 from Santa Cruz Biotechnology
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SNAP 25 shRNA Plasmid (h) - sc-36517-SH from Santa Cruz Biotechnology
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SNAP 25 shRNA (h) Lentiviral Particles - sc-36517-V from Santa Cruz Biotechnology
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SNAP25 RNAi - H00006616-R02 from Novus Biologicals
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SNAP25 RNAi - H00006616-R01 from Novus Biologicals
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MISSION® esiRNA - EHU064931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19822 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19822 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08522 from Sigma-Aldrich
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SNAP25 siRNA (Human) - CRH4499 from Cohesion Biosciences
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SNAP25 - MBS8213302 from MyBioSource
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shRNA set against Human SNAP25 (NM_003081.3) - SHH413872 from Creative biogene
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SNAP25 shRNA Plasmid (Human) - CHH4499 from Cohesion Biosciences
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SNAP25 miRNA 3'UTR clone - MiUTR3H-03268 from Creative biogene
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SNAP25 miRNA 3'UTR clone - MiUTR3H-03269 from Creative biogene
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