IMPDH1

Gene Symbol IMPDH1
Entrez Gene 3614
Alt Symbol IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
Species Human
Gene Type protein-coding
Description IMP (inosine 5'-monophosphate) dehydrogenase 1
Other Description IMP (inosine monophosphate) dehydrogenase 1|IMPD 1|IMPDH 1|inosine-5'-monophosphate dehydrogenase 1
Swissprots B4DE09 A4D0Z6 J3KNX8 P20839 B3KNP7 Q8N194 A6NDW5 C9JV30 A6NNI6 A4D0Z7 B3KVM8 Q96NU2
Accessions EAL24310 EAL24311 EAW83649 EAW83650 EAW83651 EAW83652 EAW83653 P20839 AK054640 BAB70780 AK054667 BAG51409 AK092452 BAG52555 AK122994 BAG53840 AK131294 BAD18464 AK293413 BAG56920 AK297943 BAG60259 BC033622 AAH33622 BX406207 CD014008 CD014010 CR933672 CAI45968 DA566139 DA980797 DC299597 DC326380 DQ598490 J05272 AAA36114 XM_005250314 XP_005250371 XM_006715967 XP_006716030 XM_006715968 XP_006716031 XM_006715969 XP_006716032 XM_006715970 XP_006716033 XM_006715971 XP_006716034 XM_011516156 XP_011514458 XM_011516157 XP_011514459 NM_000883 NP_000874 NM_001102605 NP_001096075 NM_001142573 NP_001136045 NM_001142574 NP_001136046 NM_001142575 NP_001136047 NM_001142576 NP_001136048 NM_001304521 NP_001291450 NM_183243 NP_899066
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways Purine metabolism, Drug metabolism - other enzymes

IMPDH (D-3) - sc-365171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IMPDH (D-3): sc-365171. Western blot analysis of IMPDH2 expression in non-transfected: sc-117752 (A) and mouse IMPDH2 transfected: sc-110295 (B) 293T whole cell lysates.

IMPDH (F-6) - sc-166551 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IMPDH (F-6): sc-166551. Western blot analysis of IMPDH2 expression in non-transfected: sc-117752 (A) and human IMPDH2 transfected: sc-113577 (B) 293T whole cell lysates.

IMPDH (N-17) - sc-46149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IMPDH (H-300) - sc-50510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IMPDH (H-300): sc-50510. Western blot analysis of IMPDH expression in non-transfected: sc-117752 (A) and human IMPDH transfected: sc-113577 (B) 293T whole cell lysates.

IMPDH (C-20) - sc-46147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IMPDH (C-20): sc-46147. Western blot analysis of IMPDH expression in non-transfected: sc-117752 (A) and human IMPDH transfected: sc-113577 (B) 293T whole cell lysates.

IMPDH (A-18) - sc-46146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IMPDH (A-18): sc-46146. Western blot analysis of IMPDH expression in non-transfected: sc-117752 (A) and human IMPDH transfected: sc-113577 (B) 293T whole cell lysates.

Anti-IMPDH1 antibody - ab33039 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IMPDH1 antibody (ab33039) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryIRDye 680 Conjugated Goat anti-rabbit IgG (H&L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-IMPDH1 antibody - ab84957 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IMPDH1 antibody (ab84957) at 1 µg/ml (in 5% skim milk / PBS buffer) + HeLa cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-IMPDH1 antibody - ab111229 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111229, at 3.75 µg/ml, staining IMPDH1 in formalin fixed, paraffin embedded Human breast tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.

Anti-IMPDH1 antibody - ab89048 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-IMPDH1 antibody (ab89048) at 1/500 dilution + human spleen tissue lysate at 50 µg

Anti-IMPDH1 antibody - ab123647 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IMPDH1 antibody (ab123647) at 1/100 dilution + HL60 cell line lysate at 35 µg

Anti-IMPDH1 antibody - ab55297 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IMPDH1 antibody [EPR9678(B)] - ab137120 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9678(B)
All lanes : Anti-IMPDH1 antibody [EPR9678(B)] (ab137120) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : K562 cell lysateLane 4 : Raji cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-IMPDH1 antibody [EPR9679(B)] - ab137112 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9679(B)
Flow cytometric analysis of permeabilized K562 cells labelling IMPDH1 with ab137112 (red) at 1/500 dilution or a rabbit IgG (negative) (green).

Anti-IMPDH1 Antibody (clone 1D6-E3) - LS-C36885 from LifeSpan Bioscience

Prices $415.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 1D6-E3

Anti-IMPDH1 Antibody (aa486-514, AP) - LS-C260220 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IMPDH1 Antibody (aa486-514, APC) - LS-C260221 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IMPDH1 Antibody (aa254-303) IHC-plus™ - LS-B3572 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IMPDH1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3572 concentration 5 ug/ml.

Anti-IMPDH1 Antibody (N-Terminus) IHC-plus™ - LS-B3957 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-IMPDH1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3957 concentration 3.75 ug/ml.

Anti-IMPDH1 Antibody (aa486-514, Biotin) - LS-C260222 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IMPDH1 Antibody (aa486-514, FITC) - LS-C260223 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IMPDH1 Antibody (aa83-113, AP) - LS-C260226 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IMPDH1 Antibody (aa83-113, Biotin) - LS-C260228 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IMPDH1 Antibody (aa83-113, APC) - LS-C260227 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IMPDH1 Antibody (aa83-113, FITC) - LS-C260229 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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