| Gene Symbol |
IMPDH1
|
| Entrez Gene |
3614
|
| Alt Symbol |
IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
IMP (inosine 5'-monophosphate) dehydrogenase 1
|
| Other Description |
IMP (inosine monophosphate) dehydrogenase 1|IMPD 1|IMPDH 1|inosine-5'-monophosphate dehydrogenase 1
|
| Swissprots |
B4DE09 A4D0Z6 J3KNX8 P20839 B3KNP7 Q8N194 A6NDW5 C9JV30 A6NNI6 A4D0Z7 B3KVM8 Q96NU2
|
| Accessions |
EAL24310 EAL24311 EAW83649 EAW83650 EAW83651 EAW83652 EAW83653 P20839 AK054640 BAB70780 AK054667 BAG51409 AK092452 BAG52555 AK122994 BAG53840 AK131294 BAD18464 AK293413 BAG56920 AK297943 BAG60259 BC033622 AAH33622 BX406207 CD014008 CD014010 CR933672 CAI45968 DA566139 DA980797 DC299597 DC326380 DQ598490 J05272 AAA36114 XM_005250314 XP_005250371 XM_006715967 XP_006716030 XM_006715968 XP_006716031 XM_006715969 XP_006716032 XM_006715970 XP_006716033 XM_006715971 XP_006716034 XM_011516156 XP_011514458 XM_011516157 XP_011514459 NM_000883 NP_000874 NM_001102605 NP_001096075 NM_001142573 NP_001136045 NM_001142574 NP_001136046 NM_001142575 NP_001136047 NM_001142576 NP_001136048 NM_001304521 NP_001291450 NM_183243 NP_899066
|
| Function |
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
|
| Tissue Specificity |
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
|
| Top Pathways |
Purine metabolism, Drug metabolism - other enzymes
|