IMPDH1

Gene Symbol	IMPDH1
Entrez Gene	3614
Alt Symbol	IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
Species	Human
Gene Type	protein-coding
Description	IMP (inosine 5'-monophosphate) dehydrogenase 1
Other Description	IMP (inosine monophosphate) dehydrogenase 1|IMPD 1|IMPDH 1|inosine-5'-monophosphate dehydrogenase 1
Swissprots	B4DE09 A4D0Z6 J3KNX8 P20839 B3KNP7 Q8N194 A6NDW5 C9JV30 A6NNI6 A4D0Z7 B3KVM8 Q96NU2
Accessions	EAL24310 EAL24311 EAW83649 EAW83650 EAW83651 EAW83652 EAW83653 P20839 AK054640 BAB70780 AK054667 BAG51409 AK092452 BAG52555 AK122994 BAG53840 AK131294 BAD18464 AK293413 BAG56920 AK297943 BAG60259 BC033622 AAH33622 BX406207 CD014008 CD014010 CR933672 CAI45968 DA566139 DA980797 DC299597 DC326380 DQ598490 J05272 AAA36114 XM_005250314 XP_005250371 XM_006715967 XP_006716030 XM_006715968 XP_006716031 XM_006715969 XP_006716032 XM_006715970 XP_006716033 XM_006715971 XP_006716034 XM_011516156 XP_011514458 XM_011516157 XP_011514459 NM_000883 NP_000874 NM_001102605 NP_001096075 NM_001142573 NP_001136045 NM_001142574 NP_001136046 NM_001142575 NP_001136047 NM_001142576 NP_001136048 NM_001304521 NP_001291450 NM_183243 NP_899066
Function	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity	IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways	Purine metabolism, Drug metabolism - other enzymes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IMPDH1 293T Cell Transient Overexpression Lysate(Denatured) - H00003614-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

IMPDH1 overexpression lysate - LY405238 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IMPDH1 overexpression lysate - LY420173 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

IMPDH1 overexpression lysate - LY428185 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IMPDH1 overexpression lysate - LY428186 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IMPDH1 293 Cell Lysate - 400353 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

IMPDH1 293 Cell Lysate - 403559 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IMPDH1 Overexpression Lysate (Denatured) - H00003614-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

IMPDH1 Overexpression Lysate (Native) - NBL1-11985 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

IMPDH1 Overexpression Lysate (Native) - NBL1-11986 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IMPDH1 Over-expression Lysate Product - GWB-102C26 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

IMPDH1 Over-expression Lysate Product - GWB-4E25A2 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human IMPDH1 Knockdown Stable Cell Line - CSC-DC007633 from Creative biogene Category Cell Line Species Human

Human IMPDH1 Knockout Cell Line-HEK293T - CSC-RT1205 from Creative biogene Category Cell Line Species Human

IMPDH1 KO Cell Lysate-HEK293T - CLKO-1058 from Creative biogene Category Cell Lysate

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