IMPDH1

Gene Symbol	IMPDH1
Entrez Gene	3614
Alt Symbol	IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
Species	Human
Gene Type	protein-coding
Description	IMP (inosine 5'-monophosphate) dehydrogenase 1
Other Description	IMP (inosine monophosphate) dehydrogenase 1|IMPD 1|IMPDH 1|inosine-5'-monophosphate dehydrogenase 1
Swissprots	B4DE09 A4D0Z6 J3KNX8 P20839 B3KNP7 Q8N194 A6NDW5 C9JV30 A6NNI6 A4D0Z7 B3KVM8 Q96NU2
Accessions	EAL24310 EAL24311 EAW83649 EAW83650 EAW83651 EAW83652 EAW83653 P20839 AK054640 BAB70780 AK054667 BAG51409 AK092452 BAG52555 AK122994 BAG53840 AK131294 BAD18464 AK293413 BAG56920 AK297943 BAG60259 BC033622 AAH33622 BX406207 CD014008 CD014010 CR933672 CAI45968 DA566139 DA980797 DC299597 DC326380 DQ598490 J05272 AAA36114 XM_005250314 XP_005250371 XM_006715967 XP_006716030 XM_006715968 XP_006716031 XM_006715969 XP_006716032 XM_006715970 XP_006716033 XM_006715971 XP_006716034 XM_011516156 XP_011514458 XM_011516157 XP_011514459 NM_000883 NP_000874 NM_001102605 NP_001096075 NM_001142573 NP_001136045 NM_001142574 NP_001136046 NM_001142575 NP_001136047 NM_001142576 NP_001136048 NM_001304521 NP_001291450 NM_183243 NP_899066
Function	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity	IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways	Purine metabolism, Drug metabolism - other enzymes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IMPDH1 full length protein - ab97410 from Abcam Category Protein Source E. coli Species Human

Human IMPDH1 peptide - ab33037 from Abcam Category Peptide

Human IMPDH1 peptide - ab33038 from Abcam Category Peptide

IMPDH1-Antibody-C-term-Blocking-peptide - BP13549b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IMPDH1-Antibody-N-term-Blocking-Peptide - BP14691a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IMPDH1 Protein (OPPA02320) - OPPA02320 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

IMPDH1 protein (His tag) - 80R-1349 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

IMPDH1 / IMPD1 (1-514, His-tag) - AR09523PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

IMPDH1 / IMPD1 (1-514, His-tag) - AR09523PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

IMPDH1 / IMPD1 - H00003614-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IMPDH1 / IMPD1 - H00003614-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IMPDH1 / IMPD1 - H00003614-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IMPDH1 / IMPD1 - H00003614-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IMPDH1, 1-514aa, Human, His tag, E.coli - 01-1851-1 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

IMPDH1 fusion protein - Ag17297 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

IMPDH1 fusion protein - ag4246 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

IMPDH1 fusion protein - Ag17473 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

IMPDH1 Human - ENPS-532 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human IMPDH1 - BP000575-ENZ-525 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

IMPDH1, 1-514aa, Recombinant Protein - GWB-P1452I from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human IMPDH1, His-tagged - IMPDH1-2580H from Creative Biomart Category Protein Source E.coli.

Recombinant Human IMPDH1, His-tagged - IMPDH1-28268TH from Creative Biomart Category Protein Source E. coli

IMPDH1 1-514aa - CMB-419 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

IMPDH1 Human - JNV-838 from Reagent Proteins Category Protein Prices $348.00, $5,685.00 Sizes 10.00 µg, 1 mg Source E.coli Species Human

Recombinant Candida albicans 40S ribosomal protein S1(RPS1) - CSB-YP328191CZD CSB-EP328191CZD CSB-BP328191CZD CSB-MP328191CZD from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Candida

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