FLCN

Gene Symbol FLCN
Entrez Gene 201163
Alt Symbol BHD, FLCL
Species Human
Gene Type protein-coding
Description folliculin
Other Description BHD skin lesion fibrofolliculoma protein|birt-Hogg-Dube syndrome protein
Swissprots Q96BE4 Q8NFG4 Q6ZRX1 Q96BD2 A6NJJ8
Accessions CAM35387 EAW55715 EAW55716 Q8NFG4 AF517523 AAM94803 AK126951 BAC86760 AK127912 BAC87186 AK309336 AL831885 CAD38565 BC015687 AAH15687 BC015725 AAH15725 BQ423946 CX759825 DA461022 DA944035 HQ447198 ADQ31685 XM_011523714 XP_011522016 XM_011523715 XP_011522017 XM_011523716 XP_011522018 XM_011523717 XP_011522019 XM_011523718 XP_011522020 XM_011523719 XP_011522021 XM_011523720 XP_011522022 XM_011523721 XP_011522023 XR_934007 NM_144606 NP_653207 NM_144997 NP_659434
Function May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:12204536, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.
Subcellular Location Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
Tissue Specificity Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach. {ECO:0000269|PubMed:12204536}.
Top Pathways Renal cell carcinoma

FLCN (D14G9) Rabbit mAb - 3697 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D14G9
Western blot analysis of extracts from various cell lines using FLCN (D14G9) Rabbit mAb.

folliculin (D-4) - sc-271558 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
folliculin (D-4): sc-271558. Western blot analysis of folliculin expression in non-transfected: sc-110760 (A) and human folliculin transfected: sc-112237 (B) 293 whole cell lysates.

folliculin (C-18) - sc-25168 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
folliculin (C-18): sc-25168. Western blot analysis of folliculin expression in non-transfected: sc-110760 (A) and human folliculin transfected: sc-112237 (B) 293 whole cell lysates.

folliculin (FL-342) - sc-25777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
folliculin (FL-342): sc-25777. Immunoperoxidase stain-ing of formalin fixed, paraffin-embedded human nasopharynx tissue showing nuclear and cytoplasmic staining of respiratory epithelial cells.

Anti-FLCN antibody - ab87753 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling FLCN with ab87753 at 1/1000 (1µg/ml). Detection: DAB.

Anti-FLCN antibody - ab93196 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FLCN antibody (ab93196) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-FLCN antibody - ab176707 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human linitis plastica stomach cancer tissue labeling FLCN with ab176707 at 1/250 dilution, followed by DAB staining.

Anti-FLCN antibody [EPNCIR147] - ab124885 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPNCIR147
All lanes : Anti-FLCN antibody [EPNCIR147] (ab124885) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : NCCIT cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-FLCN antibody - C-terminal - ab187311 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FLCN antibody - C-terminal (ab187311) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : HeLa total cell extractLane 3 : Jurkat total cell extract

Anti-FLCN / Folliculin Antibody (Internal, AP) - LS-C244410 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (Internal, Biotin) - LS-C244412 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (Internal, APC) - LS-C244411 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (Internal, FITC) - LS-C244413 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (C-Terminus, APC) - LS-C244415 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (C-Terminus, AP) - LS-C244414 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (Internal, PE) - LS-C244416 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (C-Terminus, FITC) - LS-C244418 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (C-Terminus, Biotin) - LS-C244417 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (aa48-97) - LS-C145402 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FLCN / Folliculin antibody LS-C145402 Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.

Anti-FLCN / Folliculin Antibody (aa506-555) - LS-C145628 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FLCN / Folliculin antibody LS-C145628 Western blot of HCT15 Cell lysate. Antibody concentration 1 ug/ml.

Anti-FLCN / Folliculin Antibody (C-Terminus, PE) - LS-C244419 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (Internal, Azide-free, HRP) - LS-C247586 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (C-Terminus, Azide-free, HRP) - LS-C247587 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody - LS-C293968 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLCN / Folliculin Antibody (C-Terminus) - LS-C327392 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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