FLCN

Gene Symbol	FLCN
Entrez Gene	201163
Alt Symbol	BHD, FLCL
Species	Human
Gene Type	protein-coding
Description	folliculin
Other Description	BHD skin lesion fibrofolliculoma protein|birt-Hogg-Dube syndrome protein
Swissprots	Q96BE4 Q8NFG4 Q6ZRX1 Q96BD2 A6NJJ8
Accessions	CAM35387 EAW55715 EAW55716 Q8NFG4 AF517523 AAM94803 AK126951 BAC86760 AK127912 BAC87186 AK309336 AL831885 CAD38565 BC015687 AAH15687 BC015725 AAH15725 BQ423946 CX759825 DA461022 DA944035 HQ447198 ADQ31685 XM_011523714 XP_011522016 XM_011523715 XP_011522017 XM_011523716 XP_011522018 XM_011523717 XP_011522019 XM_011523718 XP_011522020 XM_011523719 XP_011522021 XM_011523720 XP_011522022 XM_011523721 XP_011522023 XR_934007 NM_144606 NP_653207 NM_144997 NP_659434
Function	May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:12204536, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
Tissue Specificity	Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach. {ECO:0000269|PubMed:12204536}.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FLCN Gene cDNA Clone - orb143215 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-FLCN-cDNA-Clone - DC04156 from Abgent, a WuXi AppTec company Prices $461.70 Sizes 10 µg Species Human Accession BC015687

FLCN - MBS1271831 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015687

Human FLCN ORF Clone(NM_144606.5) - CDCL163626 from Creative Biomart Species Human Accession NM_144606.5

Human FLCN ORF clone - CDCL108597 from Creative Biomart Species Human Accession NM_144606

Human FLCN ORF clone - CDCL108598 from Creative Biomart Species Human Accession NM_144606

Human FLCN ORF clone - CDCL108599 from Creative Biomart Species Human Accession NM_144606

Human FLCN ORF clone - CDCL108600 from Creative Biomart Species Human Accession NM_144606

Mouse FLCN ORF clone - CDCL108601 from Creative Biomart Species Human Accession NM_144606

Mouse FLCN ORF clone - CDCL108602 from Creative Biomart Species Human Accession NM_144606

Human FLCN ORF clone - CDCL108603 from Creative Biomart Species Human Accession NM_144606

Human FLCN ORF clone - CDCL108604 from Creative Biomart Species Human Accession NM_144606

Human FLCN Gene ORF cDNA clone in cloning vector - HG14386-G from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, C-HA tag - HG14386-CY from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14386-NF from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14386-CF from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14386-NM from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14386-CM from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, N-His tag - HG14386-NH from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14386-ANG from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, N-HA tag - HG14386-NY from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14386-ACG from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14386-ACR from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14386-ANR from Sino Biological Species Human

Human FLCN Gene ORF cDNA clone expression plasmid, C-His tag - HG14386-CH from Sino Biological Species Human

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