FLCN

Gene Symbol	FLCN
Entrez Gene	201163
Alt Symbol	BHD, FLCL
Species	Human
Gene Type	protein-coding
Description	folliculin
Other Description	BHD skin lesion fibrofolliculoma protein|birt-Hogg-Dube syndrome protein
Swissprots	Q96BE4 Q8NFG4 Q6ZRX1 Q96BD2 A6NJJ8
Accessions	CAM35387 EAW55715 EAW55716 Q8NFG4 AF517523 AAM94803 AK126951 BAC86760 AK127912 BAC87186 AK309336 AL831885 CAD38565 BC015687 AAH15687 BC015725 AAH15725 BQ423946 CX759825 DA461022 DA944035 HQ447198 ADQ31685 XM_011523714 XP_011522016 XM_011523715 XP_011522017 XM_011523716 XP_011522018 XM_011523717 XP_011522019 XM_011523718 XP_011522020 XM_011523719 XP_011522021 XM_011523720 XP_011522022 XM_011523721 XP_011522023 XR_934007 NM_144606 NP_653207 NM_144997 NP_659434
Function	May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:12204536, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
Tissue Specificity	Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach. {ECO:0000269|PubMed:12204536}.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FLCN full length protein - ab165879 from Abcam Category Protein Source Wheat germ Species Human

Human FLCN protein fragment - ab165880 from Abcam Category Protein Source Wheat germ Species Human

FLCN / Folliculin Antibody Blocking Peptide - LS-E22486 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FLCN / Folliculin Antibody Blocking Peptide - LS-E22487 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FLCN / Folliculin Antibody Blocking Peptide - LS-E9706 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FLCN / Folliculin Antibody Blocking Peptide - LS-E9705 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Folliculin Partial Recombinant Protein - H00201163-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Folliculin Protein - H00201163-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

FLCN-Antibody-Center-Blocking-Peptide - BP8658c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FLCN-Antibody-C-term-Blocking-Peptide - BP8658b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FLCN Blocking Peptide - 33R-2358 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FLCN Blocking Peptide - 33R-10310 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Folliculin - H00201163-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

Folliculin - H00201163-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Folliculin - H00201163-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FLCN fusion protein - ag1746 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Folliculin Peptide - 350516 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Folliculin (FLCN) - RPJ102Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Folliculin(FLCN) - CSB-YP008711HU CSB-EP008711HU CSB-BP008711HU CSB-MP008711HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Folliculin (transcript variant 1) - TP320396 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Folliculin Recombinant Protein Antigen - NBP1-89983PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FLCN Peptide, Human - M34GP05774H from Creative Peptides Category Peptide Source Synthetic. Species Human

Folliculin (FLCN), Recombinant Protein - MBS1402604 from MyBioSource Category Protein Prices $1,380.00, $1,380.00, $1,595.00, $1,595.00, $2,295.00, $2,295.00, $2,760.00, $2,760.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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