FLCN

Gene Symbol FLCN
Entrez Gene 201163
Alt Symbol BHD, FLCL
Species Human
Gene Type protein-coding
Description folliculin
Other Description BHD skin lesion fibrofolliculoma protein|birt-Hogg-Dube syndrome protein
Swissprots Q96BE4 Q8NFG4 Q6ZRX1 Q96BD2 A6NJJ8
Accessions CAM35387 EAW55715 EAW55716 Q8NFG4 AF517523 AAM94803 AK126951 BAC86760 AK127912 BAC87186 AK309336 AL831885 CAD38565 BC015687 AAH15687 BC015725 AAH15725 BQ423946 CX759825 DA461022 DA944035 HQ447198 ADQ31685 XM_011523714 XP_011522016 XM_011523715 XP_011522017 XM_011523716 XP_011522018 XM_011523717 XP_011522019 XM_011523718 XP_011522020 XM_011523719 XP_011522021 XM_011523720 XP_011522022 XM_011523721 XP_011522023 XR_934007 NM_144606 NP_653207 NM_144997 NP_659434
Function May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:12204536, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.
Subcellular Location Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
Tissue Specificity Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach. {ECO:0000269|PubMed:12204536}.
Top Pathways Renal cell carcinoma

folliculin CRISPR/Cas9 KO Plasmid (h) - sc-403316 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

folliculin HDR Plasmid (h) - sc-403316-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

folliculin Double Nickase Plasmid (h) - sc-403316-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

folliculin Double Nickase Plasmid (h2) - sc-403316-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

folliculin CRISPR Activation Plasmid (h) - sc-403316-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

folliculin CRISPR Activation Plasmid (h2) - sc-403316-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

folliculin Lentiviral Activation Particles (h) - sc-403316-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

folliculin Lentiviral Activation Particles (h2) - sc-403316-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Folliculin siRNA (h) - sc-37412 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Folliculin shRNA Plasmid (h) - sc-37412-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Folliculin shRNA (h) Lentiviral Particles - sc-37412-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Folliculin RNAi - H00201163-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU006461 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8728 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8728 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09692 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09692

FLCN siRNA (Human) - CRJ6278 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Folliculin RNAi - H00201163-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

FLCN - MBS8201345 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FLCN (NM_144606.5) - SHH295385 from Creative biogene

Category siRNA
Species Reactivities Human

Human FLCN siRNA - orb276779 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FLCN shRNA Plasmid (Human) - CHJ6278 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FLCN miRNA 3'UTR clone - MiUTR3H-09104 from Creative biogene

Species Reactivities Human

FLCN miRNA 3'UTR clone - MiUTR3H-09105 from Creative biogene

Species Reactivities Human
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