| Gene Symbol |
SF3B4
|
| Entrez Gene |
10262
|
| Alt Symbol |
AFD1, Hsh49, SAP49, SF3b49
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
splicing factor 3b, subunit 4, 49kDa
|
| Other Description |
SAP 49|SF3b50|pre-mRNA-splicing factor SF3b 49 kDa subunit|spliceosomal protein|spliceosome-associated protein (U2 snRNP)|spliceosome-associated protein 49|splicing factor 3B subunit 4|splicing factor 3b, subunit 4, 49kD
|
| Swissprots |
Q15427 Q5SZ63
|
| Accessions |
AAA60300 CAI12553 CAI12554 CAI12647 CAI12648 EAW53595 Q15427 AI925089 AK097315 BAG53452 AK223322 BAD97042 AK310495 BC004273 AAH04273 BC013886 AAH13886 BC090883 AAH90883 BM460550 DA535996 DQ892971 ABM83897 DQ896220 ABM87219 EU176749 ABW03550 NM_005850 NP_005841
|
| Function |
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Spliceosome
|
