SF3B4

Gene Symbol	SF3B4
Entrez Gene	10262
Alt Symbol	AFD1, Hsh49, SAP49, SF3b49
Species	Human
Gene Type	protein-coding
Description	splicing factor 3b, subunit 4, 49kDa
Other Description	SAP 49|SF3b50|pre-mRNA-splicing factor SF3b 49 kDa subunit|spliceosomal protein|spliceosome-associated protein (U2 snRNP)|spliceosome-associated protein 49|splicing factor 3B subunit 4|splicing factor 3b, subunit 4, 49kD
Swissprots	Q15427 Q5SZ63
Accessions	AAA60300 CAI12553 CAI12554 CAI12647 CAI12648 EAW53595 Q15427 AI925089 AK097315 BAG53452 AK223322 BAD97042 AK310495 BC004273 AAH04273 BC013886 AAH13886 BC090883 AAH90883 BM460550 DA535996 DQ892971 ABM83897 DQ896220 ABM87219 EU176749 ABW03550 NM_005850 NP_005841
Function	Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular Location	Nucleus {ECO:0000250}.
Top Pathways	Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SAP 49 CRISPR/Cas9 KO Plasmid (h) - sc-407057 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 HDR Plasmid (h) - sc-407057-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 Double Nickase Plasmid (h) - sc-407057-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 Double Nickase Plasmid (h2) - sc-407057-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 CRISPR Activation Plasmid (h) - sc-407057-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 CRISPR Activation Plasmid (h2) - sc-407057-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 Lentiviral Activation Particles (h) - sc-407057-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 Lentiviral Activation Particles (h2) - sc-407057-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 siRNA (h) - sc-38313 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SAP 49 shRNA Plasmid (h) - sc-38313-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SAP 49 shRNA (h) Lentiviral Particles - sc-38313-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SF3B4 RNAi - H00010262-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU048571 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19189 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19189 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00470 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00470

SF3B4 siRNA (Human) - CRH6946 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SF3B4 - MBS8217001 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SAP 49 CRISPR/Cas9 KO Plasmid (h2) - sc-407057-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP 49 HDR Plasmid (h2) - sc-407057-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human SF3B4 (NM_005850.4) - SHH405848 from Creative biogene Category siRNA Species Reactivities Human

Human SF3B4 siRNA - orb267448 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SF3B4 shRNA Plasmid (Human) - CHH6946 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SF3B4 miRNA 3'UTR clone - MiUTR3H-07816 from Creative biogene Species Reactivities Human

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