SF3B4

Gene Symbol SF3B4
Entrez Gene 10262
Alt Symbol AFD1, Hsh49, SAP49, SF3b49
Species Human
Gene Type protein-coding
Description splicing factor 3b, subunit 4, 49kDa
Other Description SAP 49|SF3b50|pre-mRNA-splicing factor SF3b 49 kDa subunit|spliceosomal protein|spliceosome-associated protein (U2 snRNP)|spliceosome-associated protein 49|splicing factor 3B subunit 4|splicing factor 3b, subunit 4, 49kD
Swissprots Q15427 Q5SZ63
Accessions AAA60300 CAI12553 CAI12554 CAI12647 CAI12648 EAW53595 Q15427 AI925089 AK097315 BAG53452 AK223322 BAD97042 AK310495 BC004273 AAH04273 BC013886 AAH13886 BC090883 AAH90883 BM460550 DA535996 DQ892971 ABM83897 DQ896220 ABM87219 EU176749 ABW03550 NM_005850 NP_005841
Function Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular Location Nucleus {ECO:0000250}.
Top Pathways Spliceosome

SAP 49 (D-11) - sc-514007 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAP 49 (D-11): sc-514007. Western blot analysis of SAP 49 expression in MCF7 (A) and HeLa (B) whole cell lysates.

SAP 49 (G-7) - sc-398944 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAP 49 (G-7): sc-398944. Western blot analysis of SAP 49 expression in MCF7 (A), PC-3 (B) and HeLa (C) whole cell lysates.

SAP 49 (G-12) - sc-365570 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAP 49 (G-12): sc-365570. Western blot analysis of SAP 49 expression in HeLa whole cell lysate.

SAP 49 (C-20) - sc-14276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SAP 49 (C-20): sc-14276. Western blot analysis of SAP 49 expression in MCF7 (A), PC-3 (B), SW480 (C) and HeLa (D) whole cell lysates.

SAP 49 (G-3) - sc-365571 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAP 49 (G-3): sc-365571. Western blot analysis of SAP 49 expression in non-transfected 293T: sc-117752 (A), mouse SAP 49 transfected 293T: sc-123349 (B) and MCF7 (C) whole cell lysates.

SAP 49 (H-72) - sc-366063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SAP 49 (H-72): sc-366063. Western blot analysis of SAP 49 expression in HeLa (A), Jurkat (B), NIH/3T3 (C), HEK293 (D) and A-431 (E) whole cell lysates.

SAP 49 (N-20) - sc-14273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SAP 49 (N-20): sc-14273. Western blot analysis of SAP 49 expression in non-transfected: sc-117752 (A) and mouse SAP 49 transfected: sc-123349 (B) 293T whole cell lysates.

Anti-SF3B4 antibody - ab11803 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SF3B4 antibody (ab11803)

Anti-SF3B4 Antibody (aa158-187, AP) - LS-C269097 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B4 Antibody (aa158-187, APC) - LS-C269098 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B4 Antibody (aa158-187, Biotin) - LS-C269099 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B4 Antibody (aa158-187, FITC) - LS-C269100 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B4 Antibody (aa158-187, Azide-free, HRP) - LS-C269101 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B4 Antibody (aa158-187, PE) - LS-C269102 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B4 Antibody (aa151-200) - LS-C30375 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-SF3B4 Antibody (aa49-98) - LS-C200659 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from 293 cells using SF3B4 antibody.

Anti-SF3B4 Antibody (aa157-187) - LS-C325034 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B4 Antibody (aa2-14) - LS-C55458 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (0.1 ug/ml) of HeLa lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-SF3B4 Antibody (aa158-187) - LS-C156058 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SF3B4 Antibody western blot of HeLa cell line lysates (35 ug/lane). The SF3B4 antibody detected the SF3B4 protein (arrow).

Anti-SF3B4 Antibody - LS-C333288 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SF3B4 antibody.

Anti-SF3B4 Antibody (N-Terminus) - LS-C31013 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SF3B4 antibody LS-C31013 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-SF3B4 Antibody (aa374-424) - LS-C290597 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SF3B4 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-SF3B4 antibody used for IP at 6 ug/mg lysate. SF3B4 was also immunoprecipitated by rabbit anti-SF3B4 antibody BL14223. For blotting immunoprecipitated SF3B4, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-SF3B4 Antibody (clone 3A1) IHC-plus™ - LS-B10383 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 3A1
Anti-SF3B4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10383 concentration 10 ug/ml.

SF3B4 Antibody (3A1) - NBP1-92692 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A1
Western Blot: SF3B4 Antibody (3A1) [NBP1-92692] - Western blot of HeLa cell crude extract stained with NBP1-92692. The SF3B4 (3A1) antibody runs with an apparent SDS-PAGE molecular weight 49kDa.

SF3B4 Antibody - NBP1-57419 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SF3B4 Antibody [NBP1-57419] - HepG2 cell lysate, Antibody Titration: 1.25ug/ml
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