FLNA

Gene Symbol FLNA
Entrez Gene 2316
Alt Symbol ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD
Species Human
Gene Type protein-coding
Description filamin A, alpha
Other Description actin binding protein 280|alpha-filamin|endothelial actin-binding protein|filamin-1|filamin-A|non-muscle filamin
Swissprots Q8NF52 P21333 E9KL45 Q5HY55 Q5HY53
Accessions AAA92644 AIG59194 CAA49687 CAA49690 CCH22601 CCH22602 EAW72744 EAW72745 EAW72746 EAW72747 EAW72748 P21333 AB191259 BAD52435 AB191260 BAD52436 AB371574 BAG48303 AB371575 BAG48304 AB371576 BAG48305 AB371577 BAG48306 AB371578 BAG48307 AB371579 BAG48308 AB593010 BAJ83965 AK074048 BAB84874 AK090427 BAC03408 AK125630 AK300165 BAG61947 AK304255 BAG65121 AL050396 AL157419 BC014654 AAH14654 BC028089 BC041179 AAH41179 BC067111 AAH67111 BC109289 AAI09290 BP235228 GU727643 ADU87644 X53416 CAA37495 XM_011531127 XP_011529429 XM_011531128 XP_011529430 XM_011531129 XP_011529431 XM_011531130 XP_011529432 XM_011531131 XP_011529433 NM_001110556 NP_001104026 NM_001456 NP_001447
Function Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:22121117}.
Subcellular Location Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Tissue Specificity Ubiquitous.
Top Pathways Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer

Phospho-Filamin A (Ser2152) Antibody - 4761 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HEK293 and HeLa cells, untreated or lamda phosphatase-treated, using Phospho-Filamin A (Ser2152) Antibody (upper) and Filamin A Antibody #4762 (lower).

Filamin A Antibody - 4762 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells, using Filamin A Antibody.

Filamin 1 (G-9) - sc-271440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 1 (G-9): sc-271440. Western blot analysis of Filamin 1 expression in HeLa whole cell lysate.

Filamin 1 (E-3) - sc-17749 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 1 siRNA (h): sc-35374. Immunofluorescence staining of methanol-fixed, control HeLa (A) and Filamin 1 siRNA silenced HeLa (B) cells showing diminished peripheral cytoplasmic staining in the siRNA silenced cells. Cells probed with Filamin 1 (E-3): sc-17749.

Filamin 1 (3F180) - sc-71118 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 1 (3F180): sc-71118. Immunofluorescence staining of methanol-fixed HeLa cells showing peripheral cytoplasmic localization.

Filamin 1 (H-300) - sc-28284 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Filamin 1 (H-300): sc-28284. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoskeletal localization.

Filamin 1 (1.BB.804) - sc-58762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 1 (1.BB.804): sc-58762. Immunofluorescence staining of methanol-fixed HeLa cells showing peripheral cytoplasmic localization.

Filamin 1 (N-19) - sc-7565 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Filamin 1 (N-19): sc-7565. Western blot analysis of Filamin 1 expression in A-431 whole cell lysate.

Filamin 1 (PM6/317) - sc-58764 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 1 (PM6/317): sc-58764. Western blot analysis of Filamin 1 expression in HeLa (A) and U-87 MG (B) whole cell lysates.

Filamin 1 (FLMN01) - sc-58763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 1 (FLMN01): sc-58763. Immunofluorescence staining of methanol-fixed HeLa cells showing peripheral cytoplasmic localization.

Filamin 1 (5) - sc-135906 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Filamin 1 (5): sc-135906. Western blot analysis of Filamin 1 expression in human endothelial tissue extract.

p-Filamin 1 (Ser 2151) - sc-130190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

p-Filamin 1 (Tyr 1046) - sc-130599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Filamin A (phospho S1083) antibody [EPR2308] - ab109269 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2308
All lanes : Anti-Filamin A (phospho S1083) antibody [EPR2308] (ab109269) at 1/1000 dilutionLane 1 : HeLa cell lysate, untreatedLane 2 : HeLa cell lysate, treated with epidermal growth factor (EGF) Lysates/proteins at 10 µg per lane.

Anti-Filamin A (phospho S1458) antibody [EP2309Y] - ab68424 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2309Y
All lanes : Anti-Filamin A (phospho S1458) antibody [EP2309Y] (ab68424) at 1/5000 dilutionLane 1 : HeLa cell lysate - untreatedLane 2 : HeLa cell lysate - treated with APLysates/proteins at 10 µg per lane.SecondaryHRP-labelled Goat anti-Rabbit antibody at 1/2000 dilution

Anti-Filamin A (phospho S2152) antibody - ab192171 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Filamin A (phospho S2152) antibody (ab192171) at 1/500 dilutionLane 1 : EGF treated 293 whole cell lysates treated with the antigen-specific peptideLane 2 : EGF treated 293 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Filamin A (phospho S2152) antibody - ab51229 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Filamin A (phospho S2152) antibody (ab51229) at 1/300 dilutionLane 1 : 293 cell lysate stimulated with EGF (200ng/ml, 5min) with immunizing (blocking) peptideLane 2 : 293 cell lysate stimulated with EGF (200ng/ml, 5min)

Anti-Filamin A (phospho S2152) antibody [EP2310AY] - ab75978 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2310AY
All lanes : Anti-Filamin A (phospho S2152) antibody [EP2310AY] (ab75978) at 1/20000 dilutionLane 1 : HeLa lysate, untreatedLane 2 : HeLa lysate, treated with calyculin ALysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Filamin A antibody - ab51217 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Filamin A antibody (ab51217) at 1/300 dilutionLane 1 : Extracts of 293 cells treated with EGF (200ng/ml, 5mins).Lane 2 : Extracts of 293 cells treated with EGF (200ng/ml, 5mins) and peptide.

Anti-Filamin A antibody - ab11074 from Abcam

Prices $398.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab11074 staining Filamin A in Human platelet cells by Flow cytometry.Cells were fixed in paraformaldehyde and permeabilized using 0.1% Triton-X-100 in 2% BSA for 15 minutes. Primary antibody used at a 1/250 dilution and incubated for 18 hours at 4°C. The secondary antibody used was an Alexa Fluor®488 conjugated donkey anti-goat IgG (H+L) at a 1/500 dilution. US: Unstained, Red Peak; IgG Ms: IgG Mouse (Isotype Control), Blue Peak; Filamin: Filamin A, Green peak.See Abreview

Anti-Filamin A antibody - ab111620 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Filamin A antibody (ab111620) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HUVEC (Human Umbilical Vein Endothelial Cell) Whole Cell LysateLane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 4 : U2OS (Human osteosarcoma cell line) Whole Cell LysateLane 5 : HT 1080 (Human fibrosarcoma) Whole Cell LysateLane 6 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Filamin A antibody - ab189183 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human uterus tissue labeling Filamin A with ab189183 at 10 µg/ml.

Anti-Filamin A antibody - ab126192 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Filamin A antibody (ab126192) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-Filamin A antibody - ab190300 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Filamin A antibody (ab190300) at 0.1 µg/ml + Human uterus lysate at 35 µgdeveloped using the ECL technique

Anti-Filamin A antibody [1273CT424.104.153] - ab188350 from Abcam

Prices $376.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 1273CT424.104.153
All lanes : Anti-Filamin A antibody [1273CT424.104.153] (ab188350) at 1/1000 dilutionLane 1 : PC-3 cell lysateLane 2 : C6 cell lysateLysates/proteins at 35 µg per lane.
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