| Gene Symbol |
DPY30
|
| Entrez Gene |
84661
|
| Alt Symbol |
Cps25, HDPY-30, Saf19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dpy-30 homolog (C. elegans)
|
| Other Description |
dpy-30-like protein|dpy-30L|protein dpy-30 homolog
|
| Swissprots |
Q9C005 D6W578
|
| Accessions |
CAD22967 CAF17541 EAX00463 EAX00464 EAX00465 EAX00466 Q9C005 AF226998 AAK00640 BC015970 AAH15970 BI752326 CD704815 XM_006712117 XP_006712180 XM_006712118 XP_006712181 XM_006712119 XP_006712182 XM_011533133 XP_011531435 NM_032574 NP_115963
|
| Function |
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19651892}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19651892}. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity). {ECO:0000250}.
|
![Western Blot: DPY30 Overexpression Lysate (Adult Normal) [NBL1-10007] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DPY30.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1777_DPY30%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10007-img0002.jpg)