| Gene Symbol |
SHPRH
|
| Entrez Gene |
257218
|
| Alt Symbol |
bA545I5.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
|
| Other Description |
2610103K11Rik|E3 ubiquitin-protein ligase SHPRH|SNF2, histone-linker, PHD and RING finger domain-containing helicase
|
| Swissprots |
Q5VV79 Q149N8 Q68DS5 Q7Z5J5 Q8N1S8 Q8NBR7 Q149N9 Q8IVE8 Q8IWQ9
|
| Accessions |
EAW47836 EAW47837 EAW47838 EAW47839 Q149N8 AA315737 AB095943 BAC23119 AK075318 BAC11544 AK094944 BAC04459 AK126959 BAG54410 AK130768 AL833521 AY161136 AAO26201 AY163808 AAO06907 BC113089 AAI13090 BC117685 AAI17686 BC117686 AAI17687 BX648322 CR749290 CAH18145 XM_006715439 XP_006715502 XM_006715440 XP_006715503 XM_006715441 XP_006715504 XM_006715443 XP_006715506 XM_011535719 XP_011534021 XM_011535720 XP_011534022 XM_011535721 XP_011534023 XM_011535722 XP_011534024 XR_245512 XR_942390 XR_942391 XR_942392 XR_942393 XR_942395 NM_001042683 NP_001036148 NM_173082 NP_775105
|
| Function |
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:18719106}.
|
| Tissue Specificity |
Broadly expressed. {ECO:0000269|PubMed:12837266}.
|