Gene Symbol | SHPRH |
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Entrez Gene | 257218 |
Alt Symbol | bA545I5.2 |
Species | Human |
Gene Type | protein-coding |
Description | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase |
Other Description | 2610103K11Rik|E3 ubiquitin-protein ligase SHPRH|SNF2, histone-linker, PHD and RING finger domain-containing helicase |
Swissprots | Q5VV79 Q149N8 Q68DS5 Q7Z5J5 Q8N1S8 Q8NBR7 Q149N9 Q8IVE8 Q8IWQ9 |
Accessions | EAW47836 EAW47837 EAW47838 EAW47839 Q149N8 AA315737 AB095943 BAC23119 AK075318 BAC11544 AK094944 BAC04459 AK126959 BAG54410 AK130768 AL833521 AY161136 AAO26201 AY163808 AAO06907 BC113089 AAI13090 BC117685 AAI17686 BC117686 AAI17687 BX648322 CR749290 CAH18145 XM_006715439 XP_006715502 XM_006715440 XP_006715503 XM_006715441 XP_006715504 XM_006715443 XP_006715506 XM_011535719 XP_011534021 XM_011535720 XP_011534022 XM_011535721 XP_011534023 XM_011535722 XP_011534024 XR_245512 XR_942390 XR_942391 XR_942392 XR_942393 XR_942395 NM_001042683 NP_001036148 NM_173082 NP_775105 |
Function | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:18719106}. |
Tissue Specificity | Broadly expressed. {ECO:0000269|PubMed:12837266}. |
SHPRH CRISPR/Cas9 KO Plasmid (h) - sc-407882 from Santa Cruz Biotechnology
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SHPRH HDR Plasmid (h) - sc-407882-HDR from Santa Cruz Biotechnology
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SHPRH Double Nickase Plasmid (h) - sc-407882-NIC from Santa Cruz Biotechnology
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SHPRH Double Nickase Plasmid (h2) - sc-407882-NIC-2 from Santa Cruz Biotechnology
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SHPRH CRISPR Activation Plasmid (h) - sc-407882-ACT from Santa Cruz Biotechnology
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SHPRH CRISPR Activation Plasmid (h2) - sc-407882-ACT-2 from Santa Cruz Biotechnology
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SHPRH Lentiviral Activation Particles (h) - sc-407882-LAC from Santa Cruz Biotechnology
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SHPRH Lentiviral Activation Particles (h2) - sc-407882-LAC-2 from Santa Cruz Biotechnology
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SHPRH siRNA (h) - sc-76493 from Santa Cruz Biotechnology
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SHPRH shRNA Plasmid (h) - sc-76493-SH from Santa Cruz Biotechnology
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SHPRH shRNA (h) Lentiviral Particles - sc-76493-V from Santa Cruz Biotechnology
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SHPRH RNAi - H00257218-R01 from Novus Biologicals
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MISSION® esiRNA - EHU023261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19313 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19313 from Sigma-Aldrich
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SHPRH siRNA (Human) - CRJ6787 from Cohesion Biosciences
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SHPRH - MBS8239545 from MyBioSource
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shRNA set against Human Shprh (NM_173082.3) - SHH407240 from Creative biogene
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SHPRH shRNA Plasmid (Human) - CHJ6787 from Cohesion Biosciences
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SHPRH miRNA 3'UTR clone - MiUTR3H-09693 from Creative biogene
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SHPRH miRNA 3'UTR clone - MiUTR3H-09694 from Creative biogene
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