CRTC2

Gene Symbol CRTC2
Entrez Gene 200186
Alt Symbol TORC-2, TORC2
Species Human
Gene Type protein-coding
Description CREB regulated transcription coactivator 2
Other Description CREB-regulated transcription coactivator 2|transducer of regulated cAMP response element-binding protein (CREB) 2
Swissprots Q8N332 Q53ET0 Q7Z3X7 Q6UUV8
Accessions Q53ET0 AF289574 AAL55758 AK096382 BAG53277 AK223559 BAD97279 AY360172 AAQ98857 AY726597 BC028886 AAH28886 BC033304 BC053562 AAH53562 BI550818 BM987537 XM_005244946 XP_005245003 XM_005244949 XP_005245006 XM_011509263 XP_011507565 XM_011509264 XP_011507566 NM_181715 NP_859066
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.
Subcellular Location Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
Tissue Specificity Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16980408}.
Top Pathways HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

TORC2/CRTC2 Antibody - 3826 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells using TORC2/CRTC2 Antibody.

TORC2/CRTC2 (5B10) Mouse mAb - 13017 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 5B10
Western blot analysis of extracts from various cell lines using TORC2/CRTC2 (5B10) Mouse mAb.

Phospho-Torc2/Crtc2 (Ser171) Antibody - 2892 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

TORC2 (A-20) - sc-46272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TORC2 (A-20): sc-46272. Western blot analysis of TORC2 expression in HeLa nuclear extract.

TORC2 (F-4) - sc-271912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TORC2 (F-4): sc-271912. Western blot analysis of TORC2 expression in Jurkat nuclear extract (A) and JAR whole cell lysate (B).

TORC2 (D-2) - sc-390765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TORC2 (D-2): sc-390765. Western blot analysis of TORC2 expression in non-transfected: sc-117752 (A) and human TORC2 transfected: sc-116557 (B) 293T whole cell lysates.

TORC2 (D-20) - sc-46273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TORC2 (D-20): sc-46273. Western blot analysis of TORC2 expression in non-transfected 293T: sc-117752 (A), mouse TORC2 transfected 293T: sc-124220 (B) and NIH/3T3 (C) whole cell lysates.

TORC2 (G-4) - sc-166445 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TORC2 (G-4): sc-166445. Western blot analysis of TORC2 expression in non-transfected: sc-117752 (A) and human TORC2 transfected: sc-116557 (B) 293T whole cell lysates.

TORC2 (H-210) - sc-67147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TORC2 (H-210): sc-67147. Western blot analysis of TORC2 expression in non-transfected: sc-117752 (A) and mouse TORC2 transfected: sc-124220 (B) 293T whole cell lysates.

TORC2 (V-13) - sc-46274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TORC2 (V-13): sc-46274. Western blot analysis of TORC2 expression in non-transfected: sc-117752 (A) and human TORC2 transfected: sc-116557 (B) 293T whole cell lysates.

Anti-TORC2 antibody - ab113408 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TORC2 antibody (ab113408) at 0.3 µg/ml + Jurkat cell lysate at 35 µgdeveloped using the ECL technique

Anti-TORC2 antibody - ab70528 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling TORC2 with ab70528 at 1/1000 (1µg/ml). Detection: DAB.

Anti-TORC2 antibody - ab89179 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-TORC2 antibody (ab89179) at 5 µg/ml + tagged, recombinant human Torc2 protein fragment (the immunogen) at 0.2 µg/ml

Anti-TORC2 antibody - ab88035 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TORC2 antibody - ab103528 from Abcam

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab103528 at 1/250 staining Torc2 in Formalin-fixed paraffin-embedded section of Human ovarian carcinoma.

Anti-TORC2 antibody [5B10] - ab105932 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B10
All lanes : Anti-TORC2 antibody [5B10] (ab105932) at 1/500 dilutionLane 1 : Hela cell lysateLane 2 : HEK293 cell lysate

Anti-TORC2 antibody [EPR3384(2)] - ab109081 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3384(2)
Anti-TORC2 antibody [EPR3384(2)] (ab109081) at 1/5000 dilution + Ins-1, rat insulinoma cell line, nuclear cell lysate at 1200000 cellsSecondaryHRP-conjugated Goat anti-rabbit IgG polyclonal at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TORC2 antibody - C-terminal - ab167129 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TORC2 antibody - C-terminal (ab167129) at 0.5 µg/mlLane 2 : Anti-TORC2 antibody - C-terminal (ab167129) at 1 µg/mlLane 1 : Human small intestine tissue lysateLane 2 : Human small intestine tissue lysateLysates/proteins at 15 µg per lane.

Anti-CRTC2 / TORC2 Antibody (aa300-350) - LS-C287507 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human TORC2 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- TORC2 used at a dilution of 1:1000 (1 Detection: DAB.

Anti-CRTC2 / TORC2 Antibody (aa83-96) IHC-plus™ - LS-B9228 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Anti-CRTC2 / TORC2 antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CRTC2 / TORC2 Antibody (C-Terminus) IHC-plus™ - LS-B10101 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRTC2 / TORC2 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10101 concentration 10 ug/ml.

Anti-CRTC2 / TORC2 Antibody (aa300-350) - LS-C90626 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRTC2 / TORC2 Antibody (aa595-694) - LS-C132578 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CRTC2 / TORC2 Antibody - LS-C144236 from LifeSpan Bioscience

Host Rat
Clonality Monoclonal

Anti-CRTC2 / TORC2 Antibody - LS-C144237 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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