CRTC2

Gene Symbol CRTC2
Entrez Gene 200186
Alt Symbol TORC-2, TORC2
Species Human
Gene Type protein-coding
Description CREB regulated transcription coactivator 2
Other Description CREB-regulated transcription coactivator 2|transducer of regulated cAMP response element-binding protein (CREB) 2
Swissprots Q8N332 Q53ET0 Q7Z3X7 Q6UUV8
Accessions Q53ET0 AF289574 AAL55758 AK096382 BAG53277 AK223559 BAD97279 AY360172 AAQ98857 AY726597 BC028886 AAH28886 BC033304 BC053562 AAH53562 BI550818 BM987537 XM_005244946 XP_005245003 XM_005244949 XP_005245006 XM_011509263 XP_011507565 XM_011509264 XP_011507566 NM_181715 NP_859066
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.
Subcellular Location Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
Tissue Specificity Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16980408}.
Top Pathways HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

TORC2 CRISPR/Cas9 KO Plasmid (h) - sc-402481 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 HDR Plasmid (h) - sc-402481-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 Double Nickase Plasmid (h) - sc-402481-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 Double Nickase Plasmid (h2) - sc-402481-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 CRISPR Activation Plasmid (h) - sc-402481-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 CRISPR Activation Plasmid (h2) - sc-402481-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 Lentiviral Activation Particles (h) - sc-402481-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 Lentiviral Activation Particles (h2) - sc-402481-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC2 siRNA (h) - sc-45832 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TORC2 shRNA Plasmid (h) - sc-45832-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TORC2 shRNA (h) Lentiviral Particles - sc-45832-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TORC2 RNAi - H00200186-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU120261 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6598 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6598 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03554 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03554

CRTC2 siRNA (Human) - CRJ6241 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CRTC2 - MBS828793 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CRTC2 (NM_181715.2) - SHH269829 from Creative biogene

Category siRNA
Species Reactivities Human

Human CRTC2 siRNA - orb276742 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CRTC2 shRNA Plasmid (Human) - CHJ6241 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CRTC2 miRNA 3'UTR clone - MiUTR3H-10344 from Creative biogene

Species Reactivities Human
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