| Gene Symbol | CRTC2 |
|---|---|
| Entrez Gene | 200186 |
| Alt Symbol | TORC-2, TORC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CREB regulated transcription coactivator 2 |
| Other Description | CREB-regulated transcription coactivator 2|transducer of regulated cAMP response element-binding protein (CREB) 2 |
| Swissprots | Q8N332 Q53ET0 Q7Z3X7 Q6UUV8 |
| Accessions | Q53ET0 AF289574 AAL55758 AK096382 BAG53277 AK223559 BAD97279 AY360172 AAQ98857 AY726597 BC028886 AAH28886 BC033304 BC053562 AAH53562 BI550818 BM987537 XM_005244946 XP_005245003 XM_005244949 XP_005245006 XM_011509263 XP_011507565 XM_011509264 XP_011507566 NM_181715 NP_859066 |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus. |
| Tissue Specificity | Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16980408}. |
| Top Pathways | HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway |