CRTC2

Gene Symbol	CRTC2
Entrez Gene	200186
Alt Symbol	TORC-2, TORC2
Species	Human
Gene Type	protein-coding
Description	CREB regulated transcription coactivator 2
Other Description	CREB-regulated transcription coactivator 2|transducer of regulated cAMP response element-binding protein (CREB) 2
Swissprots	Q8N332 Q53ET0 Q7Z3X7 Q6UUV8
Accessions	Q53ET0 AF289574 AAL55758 AK096382 BAG53277 AK223559 BAD97279 AY360172 AAQ98857 AY726597 BC028886 AAH28886 BC033304 BC053562 AAH53562 BI550818 BM987537 XM_005244946 XP_005245003 XM_005244949 XP_005245006 XM_011509263 XP_011507565 XM_011509264 XP_011507566 NM_181715 NP_859066
Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.
Subcellular Location	Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
Tissue Specificity	Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16980408}.
Top Pathways	HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TORC2 full length protein - ab165858 from Abcam Category Protein Source Wheat germ Species Human

Human TORC2 protein fragment - ab165859 from Abcam Category Protein Source Wheat germ Species Human

CRTC2 / TORC2 Antibody Blocking Peptide - LS-E3034 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRTC2 / TORC2 Antibody Blocking Peptide - LS-E3173 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRTC2 / TORC2 Antibody Blocking Peptide - LS-E27678 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRTC2 / TORC2 Antibody Blocking Peptide - LS-E27679 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRTC2 / TORC2 Antibody Blocking Peptide - LS-E27605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRTC2 / TORC2 Antibody Blocking Peptide - LS-E27606 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRTC2 / TORC2 Antibody Blocking Peptide - LS-E31432 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TORC2 Protein - H00200186-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human TORC2 Protein - H00200186-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CRTC2-Antibody-C-term-Blocking-Peptide - BP14167b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CRTC2-Antibody-N-term-Blocking-Peptide - BP14321a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TORC2 Blocking Peptide - 33R-11024 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

TORC2 Peptide - AC21-2424-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TORC2 Peptide - AC21-2425-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TORC2 Peptide - AC21-2850-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CRTC2 / TORC2 - H00200186-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CRTC2 / TORC2 - H00200186-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CRTC2 / TORC2 - H00200186-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CRTC2 / TORC2 Control Peptide - AP10353CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

CRTC2 Peptide - 7325P from ProSci Category Peptide Species Human

CRTC2 Peptide - 42-852P from ProSci Category Peptide Species Mouse, Rat

CRTC2 Peptide - 42-407P from ProSci Category Peptide Species Human

CRTC2,TORC2 fusion protein - Ag3167 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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