SH3BP4

Gene Symbol SH3BP4
Entrez Gene 23677
Alt Symbol BOG25, TTP
Species Human
Gene Type protein-coding
Description SH3-domain binding protein 4
Other Description EH-binding protein 10|SH3 domain-binding protein 4|transferrin receptor-trafficking protein
Swissprots Q53TD1 Q53QD0 Q309A3 O95082 Q9P0V3
Accessions AAY14916 AAY24025 EAW71076 EAW71077 Q9P0V3 AF015043 AAD01551 AF147747 AAF33022 AK291209 BAF83898 AK304398 BAG65233 BC057396 AAH57396 BX647198 BX648877 DQ232895 ABB18377 XM_011510891 XP_011509193 XM_011510892 XP_011509194 XM_011510893 XP_011509195 XM_011510894 XP_011509196 NM_014521 NP_055336
Function May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.
Subcellular Location Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Tissue Specificity Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). {ECO:0000269|PubMed:10644451, ECO:0000269|PubMed:15616480}.

SH3BP4 (A-6) - sc-393730 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SH3BP4 (A-6): sc-393730. Western blot analysis of SH3BP4 expression in non-transfected 293T: sc-117752 (A), mouse SH3BP4 transfected 293T: sc-123533 (B) and HeLa (C) whole cell lysates and human lung tissue extract (D).

SH3BP4 (H-193) - sc-368599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

SH3BP4 (C-13) - sc-162187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SH3BP4 (S-17) - sc-162189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SH3BP4 (S-17): sc-162189. Western blot analysis of SH3BP4 expression in non-transfected: sc-117752 (A) and mouse SH3BP4 transfected: sc-123533 (B) 293T whole cell lysates.

Anti-SH3BP4 antibody - ab106609 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-SH3BP4 antibody (ab106609) at 1 µg/mlLane 2 : Anti-SH3BP4 antibody (ab106609) at 2 µg/mlLane 1 : Rat lung tissue lysateLane 2 : Rat lung tissue lysateLysates/proteins at 15 µg per lane.

Anti-SH3BP4 antibody - ab57005 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57005 SH3BP4 antibody at 1ug/ml.

Anti-SH3BP4 antibody [2992C1a] - ab84853 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2992C1a
Anti-SH3BP4 antibody [2992C1a] (ab84853) + Immunogen (Recombinant Human SH3BP4 fragment)

Anti-SH3BP4 Antibody (clone 2992C1a) - LS-C184730 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2992C1a

Anti-SH3BP4 Antibody (aa402-429, APC) - LS-C224065 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3BP4 Antibody (aa402-429, AP) - LS-C224064 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3BP4 Antibody (aa402-429, Biotin) - LS-C224066 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3BP4 Antibody (aa402-429, Azide-free, HRP) - LS-C224068 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3BP4 Antibody (aa402-429, FITC) - LS-C224067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3BP4 Antibody (aa402-429, PE) - LS-C224070 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3BP4 Antibody (aa401-429) - LS-C325085 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3BP4 Antibody (aa71-120) - LS-C116600 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SH3BP4 antibody LS-C116600 Western blot of ACHN lysate.

Anti-SH3BP4 Antibody (clone 2992C1a) - LS-C342761 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2992C1a
Western blot analysis of immunized recombinant protein, using anti-SH3BP4 monoclonal antibody.

Anti-SH3BP4 Antibody (aa402-429) - LS-C156074 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SH3BP4 Antibody western blot of 293 cell line lysates (35 ug/lane). The SH3BP4 antibody detected the SH3BP4 protein (arrow).

Anti-SH3BP4 Antibody (aa105-154) - LS-C201646 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human THP-1. SH3BP4 antibody dilution 1.0 ug/ml.

Anti-SH3BP4 Antibody (C-Terminus) IHC-plus™ - LS-B4604 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SH3BP4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4604 concentration 5 ug/ml.

SH3BP4 Antibody - NBP1-77031 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SH3BP4 Antibody [NBP1-77031] - Rat lung tissue lysate with SH3BP4 antibody at (A) 1 and (B) 2 ug/mL.

SH3BP4 Antibody - NBP2-38352 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SH3BP4 Antibody [NBP2-38352] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative Control. Lane 3: Overexpression lysate

SH3BP4 Antibody - NBP1-86274 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SH3BP4 Antibody - NBP1-71986 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SH3BP4 Antibody [NBP1-71986] - Staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

SH3BP4 Antibody (3F3) - H00023677-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F3
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