| Gene Symbol | SH3BP4 |
|---|---|
| Entrez Gene | 23677 |
| Alt Symbol | BOG25, TTP |
| Species | Human |
| Gene Type | protein-coding |
| Description | SH3-domain binding protein 4 |
| Other Description | EH-binding protein 10|SH3 domain-binding protein 4|transferrin receptor-trafficking protein |
| Swissprots | Q53TD1 Q53QD0 Q309A3 O95082 Q9P0V3 |
| Accessions | AAY14916 AAY24025 EAW71076 EAW71077 Q9P0V3 AF015043 AAD01551 AF147747 AAF33022 AK291209 BAF83898 AK304398 BAG65233 BC057396 AAH57396 BX647198 BX648877 DQ232895 ABB18377 XM_011510891 XP_011509193 XM_011510892 XP_011509194 XM_011510893 XP_011509195 XM_011510894 XP_011509196 NM_014521 NP_055336 |
| Function | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Subcellular Location | Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus. |
| Tissue Specificity | Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). {ECO:0000269|PubMed:10644451, ECO:0000269|PubMed:15616480}. |