SH3BP4

Gene Symbol SH3BP4
Entrez Gene 23677
Alt Symbol BOG25, TTP
Species Human
Gene Type protein-coding
Description SH3-domain binding protein 4
Other Description EH-binding protein 10|SH3 domain-binding protein 4|transferrin receptor-trafficking protein
Swissprots Q53TD1 Q53QD0 Q309A3 O95082 Q9P0V3
Accessions AAY14916 AAY24025 EAW71076 EAW71077 Q9P0V3 AF015043 AAD01551 AF147747 AAF33022 AK291209 BAF83898 AK304398 BAG65233 BC057396 AAH57396 BX647198 BX648877 DQ232895 ABB18377 XM_011510891 XP_011509193 XM_011510892 XP_011509194 XM_011510893 XP_011509195 XM_011510894 XP_011509196 NM_014521 NP_055336
Function May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.
Subcellular Location Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Tissue Specificity Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). {ECO:0000269|PubMed:10644451, ECO:0000269|PubMed:15616480}.

SH3BP4 293 Cell Lysate - 407172 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

SH3BP4 Overexpression Lysate (Native) - NBL1-15928 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SH3BP4 Overexpression Lysate (Adult Normal) [NBL1-15928] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SH3BP4.

SH3BP4 Over-expression Lysate Product - GWB-7DA3F9 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human SH3BP4 Knockdown Stable Cell Line - CSC-DC014172 from Creative biogene

Category Cell Line
Species Human
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