SH3BP4

Gene Symbol	SH3BP4
Entrez Gene	23677
Alt Symbol	BOG25, TTP
Species	Human
Gene Type	protein-coding
Description	SH3-domain binding protein 4
Other Description	EH-binding protein 10|SH3 domain-binding protein 4|transferrin receptor-trafficking protein
Swissprots	Q53TD1 Q53QD0 Q309A3 O95082 Q9P0V3
Accessions	AAY14916 AAY24025 EAW71076 EAW71077 Q9P0V3 AF015043 AAD01551 AF147747 AAF33022 AK291209 BAF83898 AK304398 BAG65233 BC057396 AAH57396 BX647198 BX648877 DQ232895 ABB18377 XM_011510891 XP_011509193 XM_011510892 XP_011509194 XM_011510893 XP_011509195 XM_011510894 XP_011509196 NM_014521 NP_055336
Function	May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.
Subcellular Location	Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Tissue Specificity	Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). {ECO:0000269|PubMed:10644451, ECO:0000269|PubMed:15616480}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SH3BP4 protein fragment - ab161745 from Abcam Category Protein Source Wheat germ Species Human

SH3BP4 Antibody Blocking Peptide - LS-E6598 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH3BP4 Antibody Blocking Peptide - LS-E30703 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SH3BP4 Antibody Blocking Peptide - LS-E19882 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH3BP4 Partial Recombinant Protein - H00023677-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SH3BP4 Blocking Peptide - NBP1-77031PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

SH3BP4-AntibodyCenter-Blocking-peptide - BP19380c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SH3BP4 Peptide - GTX85017-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

SH3BP4 Blocking Peptide - 33R-3104 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SH3BP4 - H00023677-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SH3BP4 - H00023677-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SH3BP4 Control Peptide - AP30775CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SH3BP4 Peptide - 5167P from ProSci Category Peptide Species Human

SH3BP4 fusion protein - Ag11847 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SH3BP4 fusion protein - Ag11957 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SH3BP4, GST-tagged - SH3BP4-2647H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human SH3 domain-binding protein 4(SH3BP4) ,partial - CSB-YP878950HU CSB-EP878950HU CSB-BP878950HU CSB-MP878950HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SH3BP4 - TP308730 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SH3BP4 Protein - NBP2-38352PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SH3BP4 Recombinant Protein Antigen - NBP1-86274PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SH3BP4 Peptide, Human - M34GP14172H from Creative Peptides Category Peptide Source Synthetic. Species Human

SH3 domain-binding protein 4 (SH3BP4), partial, Recombinant Protein - MBS1340090 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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